|本期目录/Table of Contents|

[1]刘乐云,冯诗璇,王耐艳,等.锶磷灰石@壳聚糖聚氧化乙烯@明胶复合支架制备及其生物性能探究[J].浙江理工大学学报,2019,41-42(自科六):776-785.
　LIU Leyuna,FENG Shixuana,WANG Naiyanb,et al.Preparation and biological properties of Strontium hydroxyapatite@ChitosanPEO@Gelatin composite scaffold[J].Journal of Zhejiang Sci-Tech University,2019,41-42(自科六):776-785.
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锶磷灰石@壳聚糖聚氧化乙烯@明胶复合支架制备及其生物性能探究()
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浙江理工大学学报[ISSN:1673-3851/CN:33-1338/TS]

卷:
第41-42卷
期数:
2019年自科六期
页码:
776-785
栏目:
出版日期:
2019-10-31

文章信息/Info

Title:
Preparation and biological properties of Strontium hydroxyapatite@ChitosanPEO@Gelatin composite scaffold
文章编号:
1673-3851 (2019) 11-0776-10
作者:
刘乐云; 冯诗璇; 王耐艳; 郑莹莹
浙江理工大学，a.理学院；b.材料与纺织学院，杭州 310018
Author(s):
LIU Leyuna;  FENG Shixuana;  WANG Naiyanb;  ZHENG Yingyinga
a. School of Sciences; b. College of Materials and Textiles, Zhejiang SciTech University, Hangzhou 310018, China
关键词:
壳聚糖; 明胶; 同轴电纺; 锶磷灰石; 骨组织工程; 细胞培养
分类号:
Q28
文献标志码:
A
摘要:
为了模拟自然骨的成分以及进一步提高材料的生物活性，制备羟基磷灰石@壳聚糖@明胶和锶磷灰石@壳聚糖@明胶复合支架，并对两种材料的生物性能进行表征。通过同轴电纺制备核壳结构的壳聚糖@明胶纤维；并采用化学沉积方法，在壳聚糖@明胶纤维表面沉积羟基磷灰石或锶磷灰石颗粒。结果显示：沉积锶磷灰石后，支架仍然能保持利于细胞生长的网状结构；细胞毒性实验和增殖实验结果表明，MG63细胞在支架材料上的存活率均超过70%；与羟基磷灰石@壳聚糖@明胶复合支架相比，锶磷灰石@壳聚糖@明胶复合支架的细胞存活率更高，表明该材料确实促进细胞的生长和活性。因此锶磷灰石@壳聚糖@明胶复合支架有良好的骨组织工程应用前景。

参考文献/References:

［1］ Levengood S K L, Zhang M. Chitosanbased scaffolds for bone tissue engineering［J］. Journal of Materials Chemistry B, 2014, 2(21): 31-61.
［2］ Anjum F, Lienemann P S, Metzger S, et al. Enzyme responsive GAGbased naturalsynthetic hybrid hydrogel for tunable growth factor delivery and stem cell differentiation［J］. Biomaterials, 2016, 87(5): 104-117.
［3］ Kumar A, Mandal S, Barui S, et al. Low temperature additive manufacturing of three dimensional scaffolds for bonetissue engineering applications: Processing related challenges and property assessment［J］. Materials Science & Engineering R, 2016, 103(5): 1-39.
［4］ Kim S, Kang Y, MercadoPagán  E, et al. In vitro evaluation of photocrosslinkable chitosanlactide hydrogels for bone tissue engineering［J］. Journal of Biomedical Materials Research Part B Applied Biomaterials, 2015, 102(7): 1393-1406.
［5］ Li L, Li B, Zhao M, et al. Singlestep mineralization of woodpile chitosan scaffolds with improved cell compatibility［J］. Journal of Biomedical Materials Research Part B Applied Biomaterials, 2011, 98(2): 230-237.
［6］ Deshmukh T R, Kuthe A M, Chaware S M, et al. A novel rapid prototyping and finite element methodbased development of the patientspecific temporomandibular joint implant［J］. Computer Methods in Biomechanics and Biomedical Engineering, 2012, 15(4): 363-370.
［7］ Lai G J, Shalumon K T, Chen S H, et al. Composite chitosan/silk fibroin nanofibers for modulation of osteogenic differentiation and proliferation of human mesenchymal stem cells［J］. Carbohydrate Polymers, 2014, 111: 288-297.
［8］ Sarkar S D, Farrugia B L, Dargaville T R, et al. Chitosancollagen scaffolds with nano/microfibrous architecture for skin tissue engineering［J］. Journal of Biomedical Materials Research Part A, 2013, 101(12): 3482-3492.［9］ Chesnutt B M, Viano A M, Yuan Y, et al. Design and characterization of a novel chitosan/nanocrystalline calcium phosphate composite scaffold for bone regeneration［J］. Journal of Biomedical Materials Research Part A, 2009, 88(2): 491-502.
［10］Wise J K, Alford A, Goldstein S, et al. Comparison of uncultured marrow mononuclear cells and cultureexpanded mesenchymal stem cells in 3D collagenchitosan microbeads for orthopaedic tissue engineering［J］. Tissue Engineering Part A, 2014, 20(1/2): 210-224.

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备注/Memo

备注/Memo:
收稿日期：2019-01-17
网络出版日期： 2019-04-03
基金项目：国家自然科学基金项目(51603187)
作者简介：刘乐云（1994-），女，江西上饶人，硕士研究生，主要从事生物复合材料的制备及生物性能方面的研究
通信作者：郑莹莹，E-mail:zhengyy1718@zstu.edu.cn
更新日期/Last Update: 2019-11-25