|本期目录/Table of Contents|

[1]张海涛,骆菁菁,邢同海,等.SF/PCL-BSA皮芯结构纳米纤维支架的制备及缓释性能[J].浙江理工大学学报,2015,33-34(自科6):766-770.
　ZHANG Hai tao,LUO Jing jing,XING Tong hai,et al.Preparation and Slow Release Properties of Nanofibrous Scaffolds with SF/PCLBSA Sheathcore Structure[J].Journal of Zhejiang Sci-Tech University,2015,33-34(自科6):766-770.
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SF/PCL-BSA皮芯结构纳米纤维支架的制备及缓释性能()
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浙江理工大学学报[ISSN:1673-3851/CN:33-1338/TS]

卷:
第33-34卷
期数:
2015年自科6期
页码:
766-770
栏目:
出版日期:
2015-11-10

文章信息/Info

Title:
Preparation and Slow Release Properties of Nanofibrous Scaffolds with SF/PCLBSA Sheathcore Structure
文章编号:
1673-3851 (2015) 06-0766-05
作者:
张海涛; 骆菁菁; 邢同海; 张洁; 熊杰
浙江理工大学，a.材料与纺织学院；b.先进纺织材料与制备技术教育部重点实验室，杭州 310018
Author(s):
ZHANG Haitao;  LUO Jingjing;  XING Tonghai;  ZHANG Jie;  XIONG Jie
a. School of Materials and Textiles; b. Key Laboratory of Advanced Textile Materials and  Manufacturing Technology, Ministry of Education, Zhejiang Sci-Tech University, Hangzhou 310018, China
关键词:
丝素蛋白; 聚己内酯; 皮芯结构; 同轴静电纺丝; 缓释性能;  纳米纤维支架
分类号:
TQ341.5
文献标志码:
A
摘要:
以丝素(SF)和聚己内酯(PCL)为皮层，牛血清白蛋白(BSA)为芯层，利用湿法静电纺丝和同轴静电纺丝相结合的方法制备三维多孔SF/PCLBSA皮芯结构纳米纤维支架，对支架的形貌和结构进行了表征，确定其工艺参数，并研究不同皮芯流率对纳米纤维支架在释放性能上的影响。结果表明：在电压15 kV，皮层流率0.3 mL/h，皮芯流率比3∶1和3∶2的工艺条件下可以得到表面形貌良好，皮芯结构明显的纳米纤维，制备的皮芯结构纳米纤维均可支持BSA近110 h的释放，无“突释”现象，皮芯流率比为3∶1时得到的纳米纤维皮层较厚，释放较缓慢，释放机制为nonfickian扩散机制；皮芯流率比为3∶2时得到的纳米纤维皮层较薄，释放较快，释放机制为骨架溶蚀机制。

参考文献/References:

［1］ Ki C S, Park S Y, Kim H J, et al. Development of 3D nanofibrous fibroin scaffold with high porosity by electrospinning: implications for bone regeneration［J］. Biotechnology Letters,2008,30(3):405-410.
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［5］ Zhang Y Z, Wang X, Feng Y, et al. Coaxial electrospinning of (fluorescein isothiocyanateconjugated bovine serum albumin)encapsulated poly (ε-caprolactone) nanofibers for sustained release［J］. Biomacromolecules,2006,7(4):1049-1057.
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备注/Memo

备注/Memo:
收稿日期： 2015-01-23
基金项目：国家自然科学基金项目(11272289)
作者简介： 张海涛(1989-)，男，河南洛阳人，硕士研究生，主要从事新纤维材料及功能性纤维材料方面的研究
通信作者： 熊杰，E-mail：jxiong@zstu.edu.cn
更新日期/Last Update: 2015-11-18