|本期目录/Table of Contents|

[1]金小康,姚舒婷,邱方燚,等.丝素蛋白/金纳米棒复合水凝胶的构建及其光热性能[J].浙江理工大学学报,2021,45-46(自科三):309-315.
 JIN Xiaokang,YAO Shuting,QIU Fangyi,et al.Construction and photothermal properties of composite hydrogel based on silk fibroin and gold nanorod[J].Journal of Zhejiang Sci-Tech University,2021,45-46(自科三):309-315.
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丝素蛋白/金纳米棒复合水凝胶的构建及其光热性能()
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浙江理工大学学报[ISSN:1673-3851/CN:33-1338/TS]

卷:
第45-46卷
期数:
2021年自科第三期
页码:
309-315
栏目:
出版日期:
2021-04-28

文章信息/Info

Title:
Construction and photothermal properties of composite hydrogel based on silk fibroin and gold nanorod
文章编号:
1673-3851 (2021) 05-0309-07
作者:
金小康姚舒婷邱方燚王秉
浙江理工大学材料科学与工程学院,杭州 310018
Author(s):
JIN Xiaokang YAO Shuting QIU Fangyi WANG Bing
School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China
关键词:
丝素蛋白金纳米棒光热性能水凝胶细胞相容性
分类号:
TB34
文献标志码:
A
摘要:
针对皮肤表面肿瘤手术切除时残留癌细胞导致肿瘤复发的医学难题,以天然高分子丝素蛋白为基体材料,包覆光热试剂金纳米棒(AuNR),制备复合水凝胶,对术后残余肿瘤癌细胞进行光热消融,以防止肿瘤复发。采用辣根过氧化物酶(HRP)对丝素蛋白分子链进行交联制备丝素蛋白水凝胶(SH),并用其负载AuNR,得到具有光热治疗作用的复合水凝胶;通过紫外吸收光谱(UV)和扫描电子显微镜(SEM)等对水凝胶材料形貌及各项性能进行表征,并以3T3细胞为体外模型,对其生物相容性进行初步研究。结果表明:合成的金纳米棒吸收峰值在800 nm左右,对波长为808 nm的近红外激光具有良好的适配性;SH与AuNR@SH水凝胶均呈现多孔蜂窝状的形貌结构,并呈现出了良好的光热性能、力学性能和可降解性能;在体外细胞相容性实验中,AuNR@SH水凝胶展现出了良好的细胞相容性,具有作为光热试剂应用的潜力。

参考文献/References:

[1] Rafiei P, Haddadi A. Docetaxelloaded PLGA and PLGAPEG nanoparticles for intravenous application: Pharmacokinetics and biodistribution profile [J]. International Journal of Nanomedicine, 2017, 12(1): 935-947.
[2] Deshpande T, Blanchard P, Wang L, et al. Radiationrelated alterations of taste function in patients with head and neck cancer: A systematic review [J]. Current Treatment Options in Oncology, 2018, 19(12): 72.
[3] Teurneau H, Engellau J, Ghanei I, et al. High recurrence rate of myxofibrosarcoma: The effect of radiotherapy is not clear [J]. Sarcoma, 2019, 2019(10): 1-8.
[4] Crichton M, Marshall S, Marx W, et al. Efficacy of ginger (Zingiber officinale) in ameliorating chemotherapyinduced naausea and vomiting and chemotherapyrelated outcomes: A systematic review update and metaanalysis [J]. Journal of the Academy of Nutrition and Dietetics, 2019, 119 (12): 2055-2068.
[5] Yue W,Chen L, Yu L, Zhou B, et al. Checkpoint blockade and nanosonosensitizeraugmented noninvasive sonodynamic therapy combination reduces tumour growth and metastases in mice [J]. Natutre Communication, 2019, 10(1): 2025-2040.
[6] Hadi M M, Nesbitt H, Masood H, et al. Investigating the performance of a novel pH and cathepsin B sensitive, stimulusresponsive nanoparticle for optimised sonodynamic therapy in prostate cancer [J]. Journal of Controled Release, 2021, 329(1): 76-86.
[7] 谭妍迪, 赵云, 刘朝奇, 等. 光声动力疗法在妇科恶性肿瘤中的应用进展[J]. 中国医学影像技术, 2020, 36(9): 1388-1391.
[8] Chen S, Lei Q, Qiu W X, et al. Mitochondriatargeting "Nanoheater" for enhanced photothermal/chemotherapy [J]. Biomaterials, 2017(12), 117: 92-104.
[9] Goncalves D P N, Park D M, Schmidt T L, et al. Modular peptidefunctionalized gold nanorods for effective glioblastoma multicellular tumor spheroid targeting [J]. Biomaterials Science, 2018, 6(5): 1140-1146.
[10] 龚玲俐, 刘含, 陆爽, 等. 近红外光促脂质体释药及光热治疗[J]. 三峡大学学报, 2020, 42(6): 107-112.

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备注/Memo

备注/Memo:
收稿日期:2020-12-22
网络出版日期:2021-02-03
基金项目:国家自然科学基金项目(51603188);浙江省自然科学基金项目(LQ15E030004);浙江理工大学基本科研业务费项目(2020Q006)
作者简介:金小康(1997-),男,湖北天门人,硕士研究生,主要从事生物医药材料方面的研究
通信作者:王秉,E-mail:wbing388@163.com
更新日期/Last Update: 2021-06-29