|本期目录/Table of Contents|

[1]薛辉,蔡玉荣,姚菊明. 微乳液法制备多孔中空羟基磷灰石微球的研究[J].浙江理工大学学报,2011,28(03):338-342.
　XUE Hui,CAI Yu rong,YAO Ju ming. Study on Porous Hydroxyapatite Microsphere with an Internal Cavity by Emulsion Method[J].Journal of Zhejiang Sci-Tech University,2011,28(03):338-342.
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 微乳液法制备多孔中空羟基磷灰石微球的研究()
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浙江理工大学学报[ISSN:1673-3851/CN:33-1338/TS]

卷:
第28卷
期数:
2011年03期
页码:
338-342
栏目:
(自科)纺织与服装工程
出版日期:
2011-06-30

文章信息/Info

Title:
 Study on Porous Hydroxyapatite Microsphere with an Internal Cavity by Emulsion Method
文章编号:
16733851 (2011) 03033805
作者:
 薛辉;  蔡玉荣;  姚菊明
 浙江理工大学先进纺织材料与制备技术教育部重点实验室， 杭州 310018
Author(s):
 XUE Hui;  CAI Yurong;  YAO Juming
 The Key Laboratory of Advanced Textile Materials and Manufacturing Technology(Zhejiang SciTech University), Ministry of Education, Hangzhou 310018, China
关键词:
 ; 羟基磷灰石;  明胶;  微乳液法;  多孔的空心微球
分类号:
TB383
文献标志码:
A
摘要:
    以自制的纳米羟基磷灰石粉末为原料，在明胶/水/植物油微乳体系中制得羟基磷灰石/明胶微球，经高温烧结将明胶去除后，得到多孔羟基磷灰石微球。采用TEM、XRD、TG、SEM、压汞仪对产品进行了表征。结果表明：利用本方法制得的羟基磷灰石微球尺寸较均匀，约为（800±200） μm；该微球呈现内部多孔结构，且孔隙率随微乳体系中明胶含量的增加而增加。当羟基磷灰石/明胶的质量比为4∶6时，微球出现空心现象。这种多孔且中空的羟基磷灰石微球在骨修复/填充和药物携带缓释方面具有潜在的应用前景。

参考文献/References:

 ［1］ Oonishi H. Orthopaedic applications of hydroxyapatite［J］. Biomaterials, 1991, 12: 171178.
［2］ Yoshikawa H, Myoui A. Bone tissue engineering with porous hydroxyapatite ceramics［J］. Journal of Artificial Organs, 2005, 8: 131136.
［3］ Boer F C Den, Wippermann B W, Blokhuis T J, et al. Healing of segmental bone defects with granular porous hydroxyapatite augmented with recombinant human osteogenic protein1 or autologous bone marrow［J］. Journal of Orthopaedic Research, 2003, 21: 521528.
［4］ Mori K, Hara T, Mizugaki T, et al. Hydroxyapatitebound cationic ruthenium complexes as novel heterogeneous lewis acid catalysts for diels?alder and aldol reactions［J］. Journal of the American Chemical Society, 2003, 125(38): 1146011461.
［5］ Suen R B, Lin S C, Hsu W H. Hydroxyapatitebased immobilized metal affinity adsorbents for protein purification［J］. Journal of Chromatography A, 2004, 1048: 3139.
［6］ Vitorino R, Lobo M J, Duarte J, et al. In vitro hydroxyapatite adsorbed salivary proteins［J］. Biochemical and Biophysical Research Communications, 2004, 320: 342346.
［7］ Lee Y J, Elzinga E J, Reeder R J. Sorption mechanisms of zinc on hydroxyapatite: systematic uptake studies and EXAFS spectroscopy analysis［J］. Environmental Science & Technology, 2005, 39: 40424048.
［8］ Cosijns A, Vervaet C, Luyten J, et al. Porous hydroxyapatite tablets as carriers for lowdosed drugs［J］. European Journal of Pharmaceutics and Biopharmaceutics, 2007, 67: 498506.
［9］ Hadinoto K, Zhu K, Tan R B H. Drug release study of large hollow nanoparticulate aggregates carrier particles for pulmonary delivery［J］. International Journal of Pharmaceutics, 2007, 341: 195206.
［10］ Komlev V S, Barinov S M, Koplik E V. A method to fabricate porous spherical hydroxyapatite granules intended for timecontrolled drug release［J］. Biomaterials, 2002, 23: 34493454.
［11］ Lee J S, Park J K. Processing of porous ceramic spheres by pseudodoubleemulsion method［J］. Ceramics International, 2003, 29: 271278.
［12］ Hong S J, Yu H S, Kim H W. Preparation of porous bioactive ceramic microspheres and in vitro osteoblastic culturing for tissue engineering application［J］. Acta Biomaterialia, 2009, 5: 17251731.

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备注/Memo

备注/Memo:
 收稿日期： 2010-09-07
基金项目： 教育部新世纪优秀人才支持计划项目（NCET070763）
作者简介： 薛辉（1985-），男，山东烟台人，硕士研究生，主要从事生物高分子材料的研究。
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