|本期目录/Table of Contents|

[1]周寅鹏,邱小雪,龚文丽,等.静电纺多孔醋酸纤维素色谱膜的制备及其蛋白吸附性能[J].浙江理工大学学报,2026,55-56(自科一):34-44.
　ZHOU Yinpeng,QIU Xiaoxue,GONG Wenli,et al.Fabrication of electrospun porous cellulose acetate membranes for chromatography and evaluation of their protein adsorption performance[J].Journal of Zhejiang Sci-Tech University,2026,55-56(自科一):34-44.
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静电纺多孔醋酸纤维素色谱膜的制备及其蛋白吸附性能()
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浙江理工大学学报[ISSN:1673-3851/CN:33-1338/TS]

卷:
55-56
期数:
2026年自科第一期
页码:
34-44
栏目:
出版日期:
2026-01-10

文章信息/Info

Title:
Fabrication of electrospun porous cellulose acetate membranes for chromatography and evaluation of their protein adsorption performance
文章编号:
1673-3851(2026) 01-0034-11
作者:
周寅鹏; 邱小雪; 龚文丽; 杨武迪; 刘琳
浙江理工大学材料科学与工程学院 ,杭州 310018
Author(s):
ZHOU Yinpeng;  QIU Xiaoxue;  GONG Wenli;  YANG Wudi;  LIU Lin
School of Materials Science & Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China
关键词:
静电纺丝; 多孔纤维膜; 蛋白吸附; 醋酸纤维素; 色谱膜
分类号:
TQ936;TQ340.64;O647.3
文献标志码:
A
摘要:
针对填料色谱柱中微球介质内扩散与轴向扩散的协同作用而导致吸附过程耗时冗长、吸附效率低下等问题 ,通过调控静电纺丝工艺参数 ,结合呼吸图法(Breathfiguremethod, BF) 制备了纤维表面开孔的多孔醋酸纤维素(Celluloseacetate, CA) 纤维膜 ,用于牛血清蛋白(Bovineserum albumin, BSA) 的吸附性能研究;在此基础上 ,探究了丙酮和二氯甲烷溶剂配比、CA质量分数、接收距离、纺丝电压和给液速率等关键参数对纤维形貌和纤维尺寸的调控规律 。结果表明:在丙酮和二氯甲烷的体积比为 1∶1、CA质量分数为 10%、接收距离为 10 cm、纺丝电压为 15kV和给液速率为 10μL/min的条件下 ,所制备的 CA纤维膜具有最佳的多孔微观形貌 。该膜纤维直径分布为 0.8~1.6μm,纤维表面呈现多孔结构 ,其平均孔径为 3.81nm, 比表面积为 17.65m2/g。 多孔 CA色谱膜对牛血清白蛋白(BSA) 的最佳吸附含量高达 129.11mg/g。其吸附行为符合 Temkin吸附等温模型与准二级动力学吸附规律 ,属于多层的化学吸附 。该研究为提升色谱分离效率提供了新思路与高性能材料 ,助力生物分离等领域的发展。

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备注/Memo

备注/Memo:
基金项目 : 国家自然科学基金项目(22375181)收稿日期 : 2025-05-27 网络出版日期 : 2025-09-18
作者简介 : 周寅鹏(1997— ) ,男 ,广西桂林人 ,硕士研究生 ,主要从事纤维素基功能材料的研究。通信作者 : 刘 琳 ,E-mail:liulin@zstu. edu. cn
更新日期/Last Update: 2026-01-08