|本期目录/Table of Contents|

[1]冯翠,赵瑞波,贾晓渊,等.间歇性禁食在裸鼠体内对肝癌进展的影响[J].浙江理工大学学报,2019,41-42(自科六):812-817.
　FENG Cuia,ZHAO Ruibob,JIA Xiaoyuana,et al.Effect of intermittent fasting on hepatocarcinoma progress in nude mice[J].Journal of Zhejiang Sci-Tech University,2019,41-42(自科六):812-817.
点击复制

间歇性禁食在裸鼠体内对肝癌进展的影响()
分享到：

浙江理工大学学报[ISSN:1673-3851/CN:33-1338/TS]

卷:
第41-42卷
期数:
2019年自科六期
页码:
812-817
栏目:
出版日期:
2019-10-31

文章信息/Info

Title:
Effect of intermittent fasting on hepatocarcinoma progress in nude mice
文章编号:
1673-3851 (2019) 11-0812-06
作者:
冯翠; 赵瑞波; 贾晓渊; 孔祥东; 陈侃
浙江理工大学，a. 生命科学与医药学院；b. 材料与纺织学院，杭州310018
Author(s):
FENG Cuia; ZHAO Ruibob; JIA Xiaoyuana; KONG Xiangdongb; CHEN Kana
a. College of Life Sciences and Medicine, b. College of Materials and Textiles, Zhejiang Sci-Tech University, Hangzhou 310018, China
关键词:
间歇性禁食; 肝癌; 肿瘤形成; Huh7细胞
分类号:
R734
文献标志码:
A
摘要:
为探究间歇性禁食对肝癌进展的影响，以皮下注射肝癌细胞Huh7的BALB/c裸鼠为研究对象，构建肿瘤模型，比较间歇性禁食对肝癌形成及生长、肝脏生理功能及血脂血糖的影响。结果显示：皮下注射Huh7细胞引起的肝癌病变，与对照组相比较，间歇性禁食组小鼠的成瘤率低，且在相同时间段内，间歇性禁食组小鼠形成的肿瘤体积较小；血清学检测结果表明，间歇性禁食组小鼠的肝损伤程度较低。间歇性禁食对肝癌形成具有一定程度的抑制作用，有望成为抑制或减缓肿瘤恶化的有效方法。

参考文献/References:

［1］ ElSerag H B, Rudolph K L. Hepatocellular carcinoma:Epidemiology and molecular carcinogenesis［J］. Gastroenterology, 2007,132(7):2557-2576.
［2］ Johnson P J, Qin S K, Park J W, et al. Brivanib versus sorafenib as firstline therapy in patients with unresectable, advanced hepatocellular carcinoma: Results from the randomized phase III BRISKFL study［J］. Journal of Clinical Oncology, 2013,31(28):3517-3524.
［3］ Su T S, Lu H Z, Cheng T, et al. Longterm survival analysis in combined transarterial embolization and stereotactic body radiation therapy versus stereotactic body radiation monotherapy for unresectable hepatocellular carcinoma ＞5cm［J］. BMC Cancer, 2016,16(1):1-9.
［4］ Lee C, Longo V D. Fasting vs dietary restriction in cellular protection and cancer treatment: From model organisms to patients［J］. Oncogene, 2011,30(30):3305-3316.
［5］ Patterson R E, Sears D D. Metabolic effects of intermittent fasting［J］. Annual Review of Nutrition, 2016, 37(1):371-393.
［6］ Brandhorst S, Longo VD. Fasting and caloricrestriction in cancer prevention and treatment［J］. Recent Results Cancer Res, 2016,207:241-266.
［7］ Fernando S, Sebastian B, Min W, et al. Fasting enhances the response of glioma to chemo and radiotherapy［J］. Plos One, 2012,7(9):1-9.
［8］ Pazienza V, Vinciguerra M, D’Aronzo M, et al. Fasting cycles potentiates the efficacy of gemcitabine treatment in in vitro and in vivo pancreatic cancer models［J］. Oncotarget, 2015,6(21):18545-18557.
［9］ Thomas J A, Poulton S H, Phillips T E, et al. Effect of intermittent fasting on prostate cancer tumor growth in a mouse model［J］. Journal of Urology, 2010,181(4):350-355.
［10］ Lankelma J, Kooi B, Krab K, et al. A reason for intermittent fasting to suppress the awakening of dormant breast tumors［J］. Biosystems, 2015,127:1-6.

相似文献/References:

[1]周驰凯,潘强.6种化合物对肝癌细胞活性影响的比较[J].浙江理工大学学报,2015,33-34(自科2):249.
　ZHOU Chi kai,PAN Qiang.Comparison of Effects of Six Chemical Compounds on Activity of Liver Cancer Cell[J].Journal of Zhejiang Sci-Tech University,2015,33-34(自科六):249.
[2]孙笑竹,吕春伟,秦云,等.CDK抑制剂SNS 032联合AD55 Apoptin对肝癌细胞Huh 7的体外抗癌作用[J].浙江理工大学学报,2016,35-36(自科2):290.
　SUN Xiaozhu,L  Chunwei,QIN Yun,et al.In vitro Antitumor Effect of Combining CDK Inhibitor SNS 032  with AD55 Apoptin on Liver Carcinoma Cell Huh[J].Journal of Zhejiang Sci-Tech University,2016,35-36(自科六):290.
[3]郑娓诗,孙艺钦,赵雪芹,等.纳米明胶硅氧烷的制备及其负载p-53基因对肝癌抑制效果[J].浙江理工大学学报,2018,39-40(自科5):605.
　ZHENG Weishi,SUN Yiqin,ZHAO Xueqin,et al.Preparation of nanogelatin siloxane and inhibition effect of its loaded p53gene on the hepatocellular carcinoma[J].Journal of Zhejiang Sci-Tech University,2018,39-40(自科六):605.
[4]杜春明,刘新垣.双基因溶瘤腺病毒OAd-mK5-shPKM2抗肝癌活性的初步探究[J].浙江理工大学学报,2019,41-42(自科一):106.
　DU Chunming,LIU Xinyuan.Antitumor effect of oncolytic adenovirus armed with mK5 and shPKM2 in liver cancer[J].Journal of Zhejiang Sci-Tech University,2019,41-42(自科六):106.

备注/Memo

备注/Memo:
收稿日期：2019-04-02
网络出版日期： 2019-09-02
基金项目：浙江省自然科学基金项目(LQ19E020010，LY18H160066，18042291-Y)
作者简介：冯翠（1991-），女，河南驻马店人，硕士研究生，主要从事生物医学工程方面的研究
通信作者：陈侃，E-mail：chenkan@zstu.edu.cn
更新日期/Last Update: 2019-11-25