|本期目录/Table of Contents|

[1]雷容,徐江晖,周文翠,等.多孔丝素颗粒的可控制备及药物负载研究[J].浙江理工大学学报,2018,39-40(自科1):37-44.
 LEI Rong,XU Jianghui,ZHOU Wencui,et al.Sizecontrolled preparation of porous silk fibroin particle used as drug carrier[J].Journal of Zhejiang Sci-Tech University,2018,39-40(自科1):37-44.
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多孔丝素颗粒的可控制备及药物负载研究()
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浙江理工大学学报[ISSN:1673-3851/CN:33-1338/TS]

卷:
第39-40卷
期数:
2018年自科1期
页码:
37-44
栏目:
出版日期:
2017-12-31

文章信息/Info

Title:
Sizecontrolled preparation of porous silk fibroin particle used as drug carrier
文章编号:
1673-3851 (2018) 01-0037-08
作者:
雷容徐江晖周文翠袁梅华蔡玉荣姚菊明
浙江理工大学材料与纺织学院,杭州 310018
Author(s):
LEI Rong XU Jianghui ZHOU Wencui YUAN Meihua CAI Yurong YAO Juming
College of Materials and Textiles, Zhejiang Sci-Tech University, Hangzhou 310018, China
关键词:
丝素纳米颗粒多孔药物负载及释放
分类号:
TB34
文献标志码:
A
摘要:
近年来桑蚕丝素蛋白以来源广泛、可降解且生物相容性好等优点,在生物医用材料领域得到了越来越广泛的关注。以丝素蛋白为原材料,研究丝素蛋白浓度、熟化温度及盐浴浓度对所制备的丝素蛋白粒径及形貌的影响,并探索该颗粒对抗肿瘤药物阿霉素的负载和控释能力。研究结果表明:丝素颗粒表面呈多孔状态的球体,粒径变化范围在400~3600 nm,对药物阿霉素的包封率为93.86%,载药量为14.08 μg/mg;随pH降低,药物释放速率和累积释放量增加。实验表明:纳米级丝素颗粒可作为药物载体,可高效包覆抗癌药物阿霉素,并实现药物的可控释放。

参考文献/References:

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[6] Sokolskypapkov M, Agashi K, Olaye A, et al. Polymer  carriers for drug delivery in tissue engineering[J]. Advanced Drug Delivery Reviews,2007,59(4/5):187-206.
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[8] Chen X J, Hou D D, Wang L, et al. Antibacterial surgical silk sutures using a highperformance slowrelease carrier coating system[J]. ACS Applied Materials & Interfaces,2015,7(40):22394-22403.
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备注/Memo

备注/Memo:
收稿日期: 2017-06-20
网络出版日期: 2017-11-09
基金项目: 国家自然科学基金项目(51372226);浙江省自然科学基金项目(LY16E020013)
作者简介: 雷容(1992-),女,湖北孝感人,硕士研究生,主要从事生物材料方面的研究
通信作者: 姚菊明,E-mail:yaoj@zstu.edu.cn
更新日期/Last Update: 2018-03-12