|本期目录/Table of Contents|

[1]林超,袁于民.PEG的分散性及结构对PEG化胶束在BSA溶液中稳定性的影响[J].浙江理工大学学报,2024,51-52(自科六):743-752.
 LIN Chao,YUAN Yumin.Effect of PEG dispersity and structure on the stability of PEG micelles in BSA solutions[J].Journal of Zhejiang Sci-Tech University,2024,51-52(自科六):743-752.
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PEG的分散性及结构对PEG化胶束在BSA溶液中稳定性的影响()
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浙江理工大学学报[ISSN:1673-3851/CN:33-1338/TS]

卷:
第51-52卷
期数:
2024年自科第六期
页码:
743-752
栏目:
出版日期:
2024-11-10

文章信息/Info

Title:
Effect of PEG dispersity and structure on the stability of PEG micelles in BSA solutions
作者:
林超袁于民
1.浙江理工大学,a.材料科学与工程学院;b.智能生物材料研究所,杭州 310018;2.浙江博美生物技术有限公司, 浙江嘉兴 314001
Author(s):
LIN Chao YUAN Yumin
1a.School of Materials Science & Engineering; 1b.Institute of Smart Biomedical Materials, Zhejiang Sci-Tech University, Hangzhou 310018, China; 2.Biomatrik Inc., Jiaxing 314001, China
关键词:
单分散PEG胶束分支结构牛血清白蛋白体外稳定性
分类号:
TQ432-2
文献标志码:
A
摘要:
聚乙二醇(Polyethylene glycol, PEG)化胶束在体外的稳定性是其作为纳米药物载体的重要参考指标。将不同分散性和结构的PEG,与十八烷酸、十四烷酸、1,2-二硬脂酸3-磷脂酰乙醇、胆固醇、维生素E琥珀酸酯、N,N双十四烷基胺和抗癌药物紫杉醇等合成一系列两亲性聚合物;分析在相同疏水段的条件下,PEG的分散性和结构对其胶束临界胶束浓度(Critical micelle concentration, CMC)、粒径以及在牛血清白蛋白(BSA)溶液中的稳定性的影响。结果显示:PEG的分散性对线形PEG化胶束的CMC和粒径影响不明显,分支结构的PEG化胶束在CMC和粒径上均显著小于线形PEG化胶束;在BSA溶液中,分支结构的PEG化胶束的稳定性显著优于线形单分散的,多分散PEG化胶束的稳定性最差,PEG结构和分散性影响胶束的体外稳定性。该文结果为开发单分散PEG化胶束的药物递送系统提供了重要的理论依据。

参考文献/References:

[1]Mundel R, Thakur T, Chatterjee M. Emerging uses of PLA-PEG copolymer in cancer drug delivery[J]. 3 Biotech, 2022, 12(2):41-52.
[2]Feng Y, Wang J, Zhang S, et al. Preparation of amentoflavone-loaded DSPE-PEG2000 micelles with improved bioavailability and in vitro antitumor efficacy[J]. Biomedical Chromatography: BMC, 2023, 37(9): 5690-5699.
[3]Hattori Y, Tamaki K, Sakasai S, et al. Effects of PEG anchors in PEGylated siRNA lipoplexes on in vitro gene-silencing effects and siRNA biodistribution in mice[J]. Molecular Medicine Reports, 2020, 22(5): 4183-4196.
[4]Sugiyama I, Sonobe T, Sadzuka Y. Effect of hybridized liposome by novel modification with some polyethyleneglycol-lipids[J]. International Journal of Pharmaceutics, 2009, 372(1): 177-183.
[5]Mu L, Feng S S. A novel controlled release formulation for the anticancer drug paclitaxel (Taxol): PLGA nanoparticles containing vitamin E TPGS[J]. Journal of Controlled Release, 2003, 86(1): 33-48.
[6]Zhao Y, Neuzil J, Wu K. Vitamin E analogues as mitochondria-targeting compounds: from the bench to the bedside?[J]. Molecular Nutrition & Food Research, 2009, 53(1): 129-139.
[7]Fortner A, Schumacher D. First COVID-19 vaccines receiving the US FDA and EMA emergency use authorization[J]. Discoveries (Craiova, Romania), 2021, 9(1): 122-130.
[8]Lu J, Chuan X, Zhang H, et al. Free paclitaxel loaded PEGylated-paclitaxel nanoparticles: Preparation and comparison with other paclitaxel systems in vitro and in vivo[J]. International Journal of Pharmaceutics, 2014, 471(1): 525-535.
[9]Teramura Y, Kuroyama K, Takai M. Influence of molecular weight of PEG chain on interaction between streptavidin and biotin-PEG-conjugated phospholipids studied with QCM-D[J]. Acta Biomaterialia, 2016, 30: 135-143.
[10]Chaudhari K R, Ukawala M, Manjappa A S, et al. Opsonization, biodistribution, cellular uptake and apoptosis study of PEGylated PBCA nanoparticle as potential drug delivery carrier[J]. Pharmaceutical Research, 2012, 29(1): 53-68.

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备注/Memo

备注/Memo:
收稿日期: 2024-03-08
网络出版日期:2024-05-08
作者简介: 林超(1995—),男,江苏盱眙人,硕士研究生,主要从事两亲性胶束方面的研究
通信作者: 袁于民,E-mail:yyuan@biomatrik.com
更新日期/Last Update: 2024-11-14