|本期目录/Table of Contents|

[1]徐阳,丁新波,祝国成,等.铜离子掺杂棒状生物活性玻璃的制备及性能研究[J].浙江理工大学学报,2026,55-56(自科五):549-560.
 XU Yang,DING Xinbo,ZHU Guocheng,et al.A study on the preparation and performance of copper-ion-doped rod-shaped bioactive glass[J].Journal of Zhejiang Sci-Tech University,2026,55-56(自科五):549-560.
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铜离子掺杂棒状生物活性玻璃的制备及性能研究()

浙江理工大学学报[ISSN:1673-3851/CN:33-1338/TS]

卷:
55-56
期数:
2026年自科第五期
页码:
549-560
栏目:
出版日期:
2026-09-20

文章信息/Info

Title:
A study on the preparation and performance of copper-ion-doped rod-shaped bioactive glass
文章编号:
1673-3851(2026) 09-0549-12
作者:
徐阳丁新波祝国成刘涛
浙江理工大学纺织科学与工程学院(国际丝绸学院)
Author(s):
XU YangDING XinboZHU GuochengLIU Tao
College of Textile Science and Engineering(International Institute of Silk) , Zhejiang Sci-Tech University, Hangzhou 310018, China
关键词:
棒状形貌 生物活性玻璃 铜离子 药物释放 释放机制
分类号:
R318.08
文献标志码:
A
摘要:
生物活性玻璃具有优异的生物活性以及良好的药物负载与释放性能 ,在治疗骨缺损疾病方面具有良好的应用前景;以棒状生物活性玻璃为基体 ,在其中添加治疗性的无机离子可以赋予更多的功能 。通过溶胶-凝胶法制备铜离子掺杂棒状生物活性玻璃(RBG@Cu) ,并对其形貌、结构和载药释药能力进行表征 。结果表明 : 随着铜离子含量的增加 ,棒状生物活性玻璃的粒径呈现先增大后减小的趋势 ,粒径最大为(413.43±69.29)nm;RBG@Cu快速诱导形成了羟基磷灰石 ,显示出良好的生物活性 ;铜离子的引入显著提升了棒状生物活性玻璃的抗菌性 ,抑菌率达99%;RBG@Cu显示出较好的药物负载与累计释放率 ,且一级模型、Korsmeyer-Peppas模型和 Weibull模型的拟合效果较优 ,R2 均达到 0.90以上 。该研究有望应用于骨组织缺损疾病方面的治疗 ,为具有优异生物活性以及良好的药物负载及释放性能的骨缺损修复材料提供技术支持。

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备注/Memo

备注/Memo:
收稿日期 : 2025-12-01 网络出版日期 : 2026-04-01基金项目 : 浙江省“尖兵”“领雁”研发攻关计划项目(2023C1194) ; 国家自然科学基金项目(31900964)作者简介 : 徐 阳 (2001— ) ,男 ,江苏扬州人 ,硕士研究生 ,主要从事生物医用纺织品方面的研究。通信作者: 丁新波,E-mail:dxblt@zstu. edu. cn0 引 言
更新日期/Last Update: 2026-09-20