|本期目录/Table of Contents|

[1]谢冉,李彬.一氧化氮释放壳聚糖复合水凝胶的制备及其抗菌性能评估[J].浙江理工大学学报,2024,51-52(自科六):753-763.
　XIE Ran,LI Bin.Preparation of a nitric oxide releasing chitosan based composite hydrogel and assessment of its antimicrobial properties[J].Journal of Zhejiang Sci-Tech University,2024,51-52(自科六):753-763.
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一氧化氮释放壳聚糖复合水凝胶的制备及其抗菌性能评估()
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浙江理工大学学报[ISSN:1673-3851/CN:33-1338/TS]

卷:
第51-52卷
期数:
2024年自科第六期
页码:
753-763
栏目:
出版日期:
2024-11-20

文章信息/Info

Title:
Preparation of a nitric oxide releasing chitosan based composite hydrogel and assessment of its antimicrobial properties
文章编号:
1673-3851 (2024)11-0753-11
作者:
谢冉; 李彬
 浙江理工大学材料科学与工程学院，杭州 310018
Author(s):
XIE Ran;  LI Bin
School of Materials Science & Engineering, Zhejiang Sci-753Tech University, Hangzhou 310018, China
关键词:
原儿茶醛; 壳聚糖; 水凝胶; 一氧化氮; 光热效应; 抗菌
分类号:
TB381
文献标志码:
A
摘要:
为了获得能够抵御细菌感染的伤口敷料，将原儿茶醛（PA）和氯化铁配位形成PA/铁离子螯合物（PA/Fe），并通过希夫碱反应与羧甲基壳聚糖（CMCS）交联形成水凝胶，在水凝胶中负载一氧化氮（NO）供体分子N,N′二仲丁基N,N′二亚硝基1,4苯二胺（BNN6）,得到BNN6@CMCS PA/Fe复合水凝胶；对BNN6@CMCS PA/Fe的结构和性能进行表征，评估其生物安全性及体外抗菌性能。结果表明：该水凝胶具有优良的力学性能和高溶胀率（1169%），能够黏附于多种材料表面，并具有自愈合能力和生物相容性；在405 nm光照下，水凝胶中的BNN6分解释放NO的速率达到了7-2 μmol/(L·h)，并且水凝胶在808 nm光照下表现出光热效应，10 min平均升温36-5 ℃；该水凝胶对金黄色葡萄球菌和大肠杆菌的生长表现出了显著的抑制效果，其中通过NO对细菌的抑菌率均超过93%，通过光热效应的抑菌率均超过99%。该研究为气体释放敷料应用于促进细菌感染伤口的愈合提供了理论依据。

参考文献/References:

［ 1 ］祖潇然 , 韩愚弟 , 周维 , 等 . 抗菌水凝胶治疗感染创面的研究进展［ J ］ . 中国修复重建外科杂志 , 2024, 38(2): 249 - 255.

［2］Cheng S, Pan M, Hu D R, et al. Adhesive chitosan-based hydrogel assisted with photothermal antibacterial property to prompt mice infected skin wound healing［J］. Chinese Chemical Letters, 2023, 34(12): 108276.

［3］Yang Z M, Fan S S, Ma W, et al. Flexible adhesive GelMA/SF-based patch embedded with polydopamine N-halamine nanoparticles for repair of infected wounds［J］. Chemical Engineering Journal, 2023, 460: 141732.

［4］Ji J Y, Ren D Y, Weng Y Z. Efficiency of multifunctional antibacterial hydrogels for chronic wound healing in diabetes: A comprehensive review［J］. International Journal of Nanomedicine, 2022, 17: 3163-3176.

［5］Liu G H, Wang L, He Y, et al. Polydopamine nanosheets doped injectable hydrogel with nitric oxide release and photothermal effects for bacterial ablation and wound healing［J］. Advanced Healthcare Materials, 2021, 10(23): 2101476.

［6］Huang W J, Cheng S, Wang X L, et al. Noncompressible hemostasis and bone regeneration induced by an absorbable bioadhesive self-healing hydrogel［J］. Advanced Functional Materials, 2021, 31(22): 2009189.

［7］唐国柯, 朱亮, 刘彦斌, 等. 壳聚糖基可注射水凝胶在骨组织修复再生方面的研究进展［J］. 生物骨科材料与临床研究, 2024, 21(2): 71-76.

［8］Bai Q, Gao Q, Hu F F, et al. Chitosan and hyaluronic-based hydrogels could promote the infected wound healing［J］. International Journal of Biological Macromolecules, 2023, 232: 123271

［9］Tan W W, Long T, Wan Y Z, et al. Dual-drug loaded polysaccharide-based self-healing hydrogels with multifunctionality for promoting diabetic wound healing［J］. Carbohydrate Polymers, 2023, 312: 120824.

［10］Shi T T, Lu H Z, Zhu J Y, et al. Naturally derived dual dynamic crosslinked multifunctional hydrogel for diabetic wound healing［J］. Composites Part B: Engineering, 2023, 257: 110687.

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备注/Memo

备注/Memo:
收稿日期： 2024-01-13
网络出版日期：2024-06-12
基金项目： 国家自然科学基金项目(52103189)
作者简介： 谢冉(1998—)，男，广东汕头人，硕士研究生，主要从事生物材料方面的研究
通信作者： 李彬，E-mail：pirute@zstu.edu.cn
更新日期/Last Update: 2024-11-14