[ 1 ] Zhang Z X, Roman G C, Hong Z, et al. Parkinson ′ s disease in China: Prevalence in Beijing, Xian, and Shanghai [ J ] . The Lancet, 2005, 365(9459): 595 - 597. [2]张森, 赵晓悦, 梁宇, 等. 帕金森病致病因素及发病机制研究进展[J]. 药学学报, 2020, 55(10): 2264-2272. [3]杨丽娟, 张京芬, 李月春, 等. 帕金森病的黑质超声表现[J]. 中华老年心脑血管病杂志, 2012,14(4):390-393. [4]蔡增林, 吴方萍, 周芯羽, 等. 早期帕金森病患者的临床与18F-FDG PET影像学特征研究[J]. 中国现代医药杂志, 2010, 12(2): 61-63. [5]Prashanth R, Dutta Roy S. Early detection of Parkinson′s disease through patient questionnaire and predictive modelling[J]. International Journal of Medical Informatics, 2018, 119: 75-87. [6]Cho C W, Chao W H, Lin S H, et al. A vision-based analysis system for gait recognition in patients with Parkinson′s disease[J]. Expert Systems With Applications, 2009, 36(3): 7033-7039. [7]Jankovic J. Parkinson′s disease: Clinical features and diagnosis[J]. Journal of Neurology, Neurosurgery, and Psychiatry, 2008, 79(4): 368-376. [8]Jahanshahi M, Jenkins I H, Brown R G, et al. Self-initiated versus externally triggered movements: I. An investigation using measurement of regional cerebral blood flow with PET and movement-related potentials in normal and Parkinson′s disease subjects[J]. Brain, 1995, 118(4): 913-933. [9]Cubo E, Martinez Martín P, Martin-Gonzalez J A, et al. Motor laterality asymmetry and nonmotor symptoms in Parkinson′s disease[J]. Movement Disorders, 2010, 25(1): 70-75. [10]Noyce A J, Nagy A, Acharya S, et al. Bradykinesia-akinesia incoordination test: Validating an online keyboard test of upper limb function[J]. PLoS One, 2014, 9(4): e96260.