|本期目录/Table of Contents|

[1]金小康,姚舒婷,邱方燚,等.丝素蛋白/金纳米棒复合水凝胶的构建及其光热性能[J].浙江理工大学学报,2021,45-46(自科三):309-315.
　JIN Xiaokang,YAO Shuting,QIU Fangyi,et al.Construction and photothermal properties of composite hydrogel based on silk fibroin and gold nanorod[J].Journal of Zhejiang Sci-Tech University,2021,45-46(自科三):309-315.
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丝素蛋白/金纳米棒复合水凝胶的构建及其光热性能()
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浙江理工大学学报[ISSN:1673-3851/CN:33-1338/TS]

卷:
第45-46卷
期数:
2021年自科第三期
页码:
309-315
栏目:
出版日期:
2021-04-28

文章信息/Info

Title:
Construction and photothermal properties of composite hydrogel based on silk fibroin and gold nanorod
文章编号:
1673-3851 (2021) 05-0309-07
作者:
金小康; 姚舒婷; 邱方燚; 王秉
浙江理工大学材料科学与工程学院，杭州 310018
Author(s):
JIN Xiaokang;  YAO Shuting;  QIU Fangyi;  WANG Bing
School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China
关键词:
丝素蛋白; 金纳米棒; 光热性能; 水凝胶; 细胞相容性
分类号:
TB34
文献标志码:
A
摘要:
针对皮肤表面肿瘤手术切除时残留癌细胞导致肿瘤复发的医学难题，以天然高分子丝素蛋白为基体材料，包覆光热试剂金纳米棒（AuNR），制备复合水凝胶，对术后残余肿瘤癌细胞进行光热消融，以防止肿瘤复发。采用辣根过氧化物酶（HRP）对丝素蛋白分子链进行交联制备丝素蛋白水凝胶（SH），并用其负载AuNR，得到具有光热治疗作用的复合水凝胶；通过紫外吸收光谱(UV)和扫描电子显微镜(SEM)等对水凝胶材料形貌及各项性能进行表征，并以3T3细胞为体外模型，对其生物相容性进行初步研究。结果表明：合成的金纳米棒吸收峰值在800 nm左右，对波长为808 nm的近红外激光具有良好的适配性；SH与AuNR@SH水凝胶均呈现多孔蜂窝状的形貌结构，并呈现出了良好的光热性能、力学性能和可降解性能；在体外细胞相容性实验中，AuNR@SH水凝胶展现出了良好的细胞相容性，具有作为光热试剂应用的潜力。

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备注/Memo

备注/Memo:
收稿日期：2020-12-22
网络出版日期：2021-02-03
基金项目：国家自然科学基金项目(51603188)；浙江省自然科学基金项目(LQ15E030004)；浙江理工大学基本科研业务费项目（2020Q006）
作者简介：金小康(1997-)，男，湖北天门人，硕士研究生，主要从事生物医药材料方面的研究
通信作者：王秉，E-mail：wbing388@163.com
更新日期/Last Update: 2021-06-29