|本期目录/Table of Contents|

[1]任旭,刘涛,朱莹,等.丝素/海藻酸钠载药复合支架的药物缓释行为及其活性[J].浙江理工大学学报,2020,43-44(自科二):209-215.
　REN Xu,LIU Tao,ZHU Ying,et al.Drug sustained release properties and bioactivity of silk fibroin/sodium alginate drugloaded composite scaffold[J].Journal of Zhejiang Sci-Tech University,2020,43-44(自科二):209-215.
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丝素/海藻酸钠载药复合支架的药物缓释行为及其活性()
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浙江理工大学学报[ISSN:1673-3851/CN:33-1338/TS]

卷:
第43-44卷
期数:
2020年自科二期
页码:
209-215
栏目:
出版日期:
2020-05-18

文章信息/Info

Title:
Drug sustained release properties and bioactivity of silk fibroin/sodium alginate drugloaded composite scaffold
文章编号:
1673-3851 (2020) 03-0209-07
作者:
任旭; 刘涛; 朱莹; 陈晓怡; 丁新波
1.浙江理工大学，a.纺织科学与工程学院，杭州 310018；b.科技与艺术学院，杭州 310018；2.浙江省人民医院临床研究所，杭州 310014
Author(s):
REN Xu;  LIU Tao;  ZHU Ying;  CHEN Xiaoyi;  DING Xinbo
1a.School of Textile Science and Engineering; 1b.Keiyi College, Zhejiang SciTech University, Hangzhou 310018c China; 2. Clinical Research Institution of Zhejiang Provincial People′s  Hospital, Hangzhou 310014, China
关键词:
丝素; 海藻酸钠; 复合支架; 药物缓释; 生物活性
分类号:
TQ341-5
文献标志码:
A
摘要:
以丝素和海藻酸钠为原材料，盐酸万古霉素为负载药物，利用冷冻干燥法制备负载盐酸万古霉素的丝素/海藻酸钠复合支架，通过扫描电子显微镜和红外光谱仪等仪器对其形貌和结构进行表征，探究丝素/海藻酸钠复合支架对盐酸万古霉素的控释能力，并通过模拟体液浸泡法来探究其样品的生物活性。结果表明：丝素/海藻酸钠复合支架均呈现出三维孔状结构，孔隙率在98%以上。在不同质量比的复合支架中，随着海藻酸钠添加比例增加，其药物缓释速率和累积释放量也有所增长；样品通过体外模拟体液浸泡后，可以观察到复合支架表面沉积了一层球状晶体的羟基磷灰石，表明样品有较好的生物活性。

参考文献/References:

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［6］ Zhang H, Liu X, Yang M, et al. Silk fibroin/sodium alginate composite nanofibrous scaffold prepared through thermally induced phaseseparation (TIPS) method for biomedical applications［J］. Materials Science and Engineering: C, 2015, 55: 8-13.
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［9］ Koh L D, Cheng Y, Teng C P, et al. Structures, mechanical properties and applications of silk fibroin materials［J］. Progress in Polymer Science, 2015, 46: 86-110.
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备注/Memo

备注/Memo:
收稿日期：2019-09-10
网络出版日期： 2019-12-02
基金项目：国家自然科学基金项目(31900964)；浙江省自然科学基金项目(LY17H180010); 科技与艺术学院科研项目(KY2019002)
作者简介：任旭(1993-)，女，河北石家庄，硕士研究生，主要从事生物医用纺织新产品的开发研究
通信作者：刘涛，E-mail：maggie_liu310@163.com
更新日期/Last Update: 2020-04-10