|本期目录/Table of Contents|

[1]郭鹏飞,贺平安.乳腺癌癌症干细胞的特异基因识别[J].浙江理工大学学报,2017,37-38(自科3):451-460.
 GUO Pengfei,HE Pingan.Identification of Specific Genes of Cancer Stem Cells of Breast Cancer[J].Journal of Zhejiang Sci-Tech University,2017,37-38(自科3):451-460.
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乳腺癌癌症干细胞的特异基因识别()
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浙江理工大学学报[ISSN:1673-3851/CN:33-1338/TS]

卷:
第37-38卷
期数:
2017年自科3期
页码:
451-460
栏目:
出版日期:
2017-05-18

文章信息/Info

Title:
Identification of Specific Genes of Cancer Stem Cells of Breast Cancer
文章编号:
1673-3851 (2017) 03-0451-10
作者:
郭鹏飞贺平安
浙江理工大学理学院,杭州 310018
Author(s):
GUO Pengfei HE Pingan
School of Sciences, Zhejiang Sci-Tech University, Hangzhou 310018, China
关键词:
乳腺癌胚胎干细胞间充质干细胞基因调控网络关键基因
分类号:
Q612
文献标志码:
A
摘要:
乳腺癌是一种严重威胁女性健康的恶性肿瘤,癌症干细胞假说的提出为乳腺癌的起因以及治疗提供了新的模型。对746个乳腺癌样本中的18409个基因和1035个miRNAs,通过生物信息学方法构建共表达网络,将其划分到不同的共表达模块中;利用胚胎干细胞和间充质干细胞的特性进一步筛选模块,得到两个大小分别为2019和859且与上述两类干细胞相关的基因集;最后通过构建这两个基因集的调控网络,筛选出两个胚胎干细胞的特异性关键基因TPX-2和MCM-10,以及间充质干细胞的特异基因COL-5A-2。这些基因可以作为癌症干细胞的候选特异性标志物,有望成为潜在的乳腺癌治疗标靶。

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期: 2016-11-22
网络出版日期: 2017-03-28
基金项目: 国家自然科学基金项目(61170110, 61272312);浙江省自然科学基金项目(LY14F020049)
作者简介: 郭鹏飞(1990-),男,山西忻州人,硕士研究生,主要从事生物信息学方面的研究
通信作者: 贺平安,E-mail:pinganhe@zstu.edu.cn
更新日期/Last Update: 2017-09-13