|本期目录/Table of Contents|

[1]吴欣欣,李晓艳,武虎,等. 丁酸钠逆转H460/5FU肺癌细胞耐药性的研究[J].浙江理工大学学报,2012,29(04):609-613.
　WU Xin xin,LI Xiao yan,WU Hu,et al. Study on the Drug Resistance Reversal of Lung Cancer CellsH460/5FU by Sodium Butyrate[J].Journal of Zhejiang Sci-Tech University,2012,29(04):609-613.
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 丁酸钠逆转H460/5FU肺癌细胞耐药性的研究()
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浙江理工大学学报[ISSN:1673-3851/CN:33-1338/TS]

卷:
第29卷
期数:
2012年04期
页码:
609-613
栏目:
(自科)生物与生命科学
出版日期:
2012-08-28

文章信息/Info

Title:
 Study on the Drug Resistance Reversal of Lung Cancer CellsH460/5FU by Sodium Butyrate
文章编号:
16733851 (2012) 04060905
作者:
 吴欣欣;  李晓艳;  武虎;  刘海燕;  陈侃
 浙江理工大学生命科学学院新元医学与生物技术研究所, 杭州 310018
Author(s):
 WU Xinxin;  LI Xiaoyan;  WU Hu;  LIU Haiyan;  CHEN Kan
 Xinyuan Institute of Medcine and Biotechnology, School of Life Sciences, Zhejiang SciTechUniversity, Hangzhou 310018, China
关键词:
 ; 肺癌;  丁酸钠;  SP细胞;  耐药逆转
分类号:
Q733.7
文献标志码:
A
摘要:
     肺癌耐药是化疗成功的主要障碍，因此肺癌细胞的耐药逆转研究具重要意义。实验通过流式细胞术检测到对5氟脲嘧啶（5Fluorouracil，5FU）耐受的细胞系H460/5FU中的SP细胞含量较亲本细胞H460明显升高，经丁酸钠诱导分化后，H460/5FU对5FU的敏感性增加，表现为细胞存活率降低，细胞凋亡率提高，而且这种改变随着丁酸钠浓度的增加而增强。结果提示丁酸钠具备逆转肺癌耐药细胞系H460/5FU耐药的能力。

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期： 2011-10-31
基金项目： 国家自然科学基金（30801379）；浙江理工大学科研启动基金（1016834-Y）；浙江省重中之重学科开放基金项目（SWYX0812）
作者简介： 吴欣欣（1986-），女，山东德州人，硕士研究生，从事癌症的靶向基因病毒治疗的研究。
通讯作者： 陈侃，电子邮箱：chenkan_xjtu@163.com
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