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[1]杨耿兵,何倩,黄青红,等. 双靶向溶瘤腺病毒联合奥沙利铂对肿瘤细胞凋亡的研究[J].浙江理工大学学报,2011,28(05):795-799.
　YANG Geng bing,HE Qian,HUANG Qing hong,et al. Study on Apoptosis of Tumor Cells Treated by DualTargeting Replicated Adenovirus Combined with Oxaliplatin[J].Journal of Zhejiang Sci-Tech University,2011,28(05):795-799.
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 双靶向溶瘤腺病毒联合奥沙利铂对肿瘤细胞凋亡的研究()
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浙江理工大学学报[ISSN:1673-3851/CN:33-1338/TS]

卷:
第28卷
期数:
2011年05期
页码:
795-799
栏目:
(自科)生物与生命科学
出版日期:
2011-10-30

文章信息/Info

Title:
 Study on Apoptosis of Tumor Cells Treated by DualTargeting Replicated Adenovirus Combined with Oxaliplatin
文章编号:
16733851 (2011) 05079505
作者:
 杨耿兵;  何倩;  黄青红;  胡徐庞;  刘立;  钱程;  骆菁菁
浙江理工大学生命科学学院， 杭州 310018
Author(s):
 YANG Gengbing;  HE Qian;  HUANG Qinghong;  HU Xupang;  LIU Li;  QIAN Cheng;  LUO Jingjing
 School of Life Sciences, Zhejiang SciTech University, Hangzhou 310018, China
关键词:
 ; 溶瘤腺病毒;  奥沙利铂;  结肠癌;  联合抑癌
分类号:
R73362
文献标志码:
A
摘要:
    研究化疗药物奥沙利铂（Oxaliplatin）联合AdCN205IL24对人结肠癌细胞的体外杀伤作用。实验采用MTT法检测肿瘤特异性增殖腺病毒AdCN205IL24联合奥沙利铂对两种肿瘤细胞以及正常细胞增殖的抑制作用； Hoechest33342染色，在荧光显微镜对病毒联合化疗诱导的肿瘤细胞凋亡进行形态学观察。结果表明：AdCN205IL24联合奥沙利铂处理4 d后对结肠癌细胞株HT29和SW620的增殖抑制率达到23.17％和22.98％，并且联合化疗并未增加对人正常细胞株L02的毒性。

参考文献/References:

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备注/Memo

备注/Memo:
 收稿日期： 2010-11-29
基金项目： 浙江省“生物医学工程”重中之重学科开放基金项目（SWYX0916）；国家自然科学基金项目（30872984）
作者简介： 杨耿兵（1981-），男，山西大同人，硕士研究生，主要从事肿瘤的靶向基因治疗研究。
通讯作者： 骆菁菁，电子邮箱：deepstoh@163.com
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