|本期目录/Table of Contents|

[1]胡秀俊,娄艳贞,吴朕煜,等.载西罗莫司聚己内酯导电可吸收编织密网支架的制备与体外性能评价[J].浙江理工大学学报,2026,55-56(自科五):648-659.
 HU Xiujun,LOU Yanzhen,WU Zhenyu,et al.Preparation and in vitro performance evaluation of sirolimus-carrying polycaprolactone conductive and absorbable woven mesh scaffolds[J].Journal of Zhejiang Sci-Tech University,2026,55-56(自科五):648-659.
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载西罗莫司聚己内酯导电可吸收编织密网支架的制备与体外性能评价()

浙江理工大学学报[ISSN:1673-3851/CN:33-1338/TS]

卷:
55-56
期数:
2026年自科第五期
页码:
648-659
栏目:
出版日期:
2026-09-20

文章信息/Info

Title:
Preparation and in vitro performance evaluation of sirolimus-carrying polycaprolactone conductive and absorbable woven mesh scaffolds
文章编号:
1673-3851(2026) 09-0648-12
作者:
胡秀俊娄艳贞吴朕煜江国华
浙江理工大学材料科学与工程学院 ,杭州 310018
Author(s):
HU XiujunLOU YanzhenWU ZhenyuJIANG Guohua
School of Materials Science& Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China
关键词:
血管支架 熔融近场直写 聚吡咯西罗莫司 电刺激 药物缓释
分类号:
R318.08
文献标志码:
A
摘要:
针对现有可降解血管支架在功能调控方面仍以被动作用为主的问题 ,运用熔融近场直写(MEW)技术 ,以聚己内酯(PCL)为基底材料、西罗莫司(RAPA)为药物组分 ,通过原位沉积聚吡咯(PPy) ,制备了具有可降解性、导电性和药物缓释功能的PCL/RAPA/PPy编织支架 ,对支架的形貌结构、力学性能、导电性能、体外降解与释药行为、血液相容性、细胞响应及电学刺激效应进行了分析 ,并结合 COMSOL仿真分析其在血管环境中的电信号响应特性。结果表明 :在所选的 RAPA 负载范围内 ,PCL/RAPA/PPy编织支架在保持整体柔性的同时其力学性能得到了提高 ,最大拉伸载荷从约 6.5 N提升到了约 9.2 N;PPy涂层的加入使支架表面形成连续的导电网络 , 支架的导电性显著提高;PCL/RAPA/PPy编织支架的溶血率低于 5% ,未观察到明显的细胞毒性 ,并在 PBS环境中表现出缓慢降解特性 ,12周后仍保持 90%以上质量;PCL/RAPA/PPy编织支架约 20d进入相对稳定的药物缓释阶段 ,可在 28d 内持续抑制大鼠主动脉平滑肌细胞迁移 ,大鼠主动脉内皮细胞在电刺激条件下仍能保持良好的铺展 ,且未出现显著的生长抑制 ;在交变磁场下PCL/RAPA/PPy编织支架具有产生感应电信号的可能性 。该研究有望为可降解导电支架在血管再生领域的后续研究提供实验依据与理论参考。

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备注/Memo

备注/Memo:
收稿日期 : 2025-12-24 网络出版日期 : 2026-04-30作者简介 : 胡秀俊(2001— ) ,男 ,浙江湖州人 ,硕士研究生 ,主要从事生物医用材料方面的研究。通信作者: 江国华,E-mail:ghjiang_cn@zstu. edu. cn
更新日期/Last Update: 2026-09-21