|本期目录/Table of Contents|

[1]葛亚威,吴珏菲,汤沁婴,等.GelMA/GA复合水凝胶的制备及其光热抗菌性能研究[J].浙江理工大学学报,2026,55-56(自科五):629-637.
　GEYawei,WUJuefei,TANGQinying,et al.Preparation and photothermal antibacterial properties of GelMA/GA composite hydrogels[J].Journal of Zhejiang Sci-Tech University,2026,55-56(自科五):629-637.
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GelMA/GA复合水凝胶的制备及其光热抗菌性能研究()

浙江理工大学学报[ISSN:1673-3851/CN:33-1338/TS]

卷:
55-56
期数:
2026年自科第五期
页码:
629-637
栏目:
出版日期:
2026-09-20

文章信息/Info

Title:
Preparation and photothermal antibacterial properties of GelMA/GA composite hydrogels
文章编号:
1673-3851(2026) 09-0629-09
作者:
葛亚威; 吴珏菲; 汤沁婴; 胡康; 章儒; 王怡; 李彬
浙江理工大学材料科学与工程学院 ,杭州 310018
Author(s):
GEYawei; WUJuefei; TANGQinying; HUKang; ZHANGRu; WANGYi; LIBin
School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China
关键词:
抗菌 ; 光热效应 ; 明胶; 阿拉伯树胶; 单宁酸 ; 铁离子
分类号:
O648.17
文献标志码:
A
摘要:
为应对传统伤口修复材料力学性能欠佳、抗菌效能不足等难题 ,开发了一种新型光热抗菌复合水凝胶敷料 GelMA/GA-TA/Fe3+ 。 以甲基丙烯酰化明胶(GelMA)与阿拉伯树胶(GA)为主体 , 通过掺杂单宁酸(TA)与Fe3+ 的络合物 ,采用光交联法制备 GelMA/GA-TA/Fe3+ 水凝胶;分析 GelMA/GA-TA/Fe3+ 水凝胶的微观形貌、力学性能、溶胀性能 ,并探究其光热抗菌能力 。结果表明 :GelMA/GA-TA/Fe3+ 水凝胶具有致密且均一的多孔网络结构 ,压缩强度达到 140kPa,为 GelMA 水凝胶的 2.5 倍 ;具备良好的吸水保湿性能 , 溶胀率约 200%; GelMA/GA- TA /Fe3+ 水凝胶表现出优秀的光热性能 ,经 2 W/cm2 的 808 nm 近红外光照射 10min后 ,其表面温度迅速从室温上升至 52.5~55.8 ℃ ,该温度可高效破坏细菌细胞膜 , 实现有效抗菌 ,对金黄色葡萄球菌和大肠埃希菌的抑菌率分别达 95.69%和 95.18% 。该研究制备的 GelMA/GA-TA/Fe3+ 水凝胶敷料兼具力学支撑、吸水保湿、光热抗菌等多方面优势 ,为治疗伤口感染的实际应用提供了新策略。

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备注/Memo

备注/Memo:
收稿日期 : 2025-12-23 网络出版日期 : 2026-04-29基金项目 : 国家自然科学基金项目(52103189) ;浙江省自然科学基金项目(LMS26E030009)作者简介 : 葛亚威(2001— ) ,男 ,山东菏泽人 ,硕士研究生 ,主要从事抗菌水凝胶方面的研究。通信作者: 李 彬,E-mail:pirute@zstu. edu. cn
更新日期/Last Update: 2026-09-21