|本期目录/Table of Contents|

[1]孙悦婷,江国华.骨碎补总黄酮/贻贝粘蛋白复合骨水泥的制备及其促骨缺损修复作用研究[J].浙江理工大学学报,2026,55-56(自科五):605-615.
　SUN Yueting,JIANG Guohua.Accelerating bone defect repair with total flavonoids of Rhizoma Drynariae and mussel adhesive protein-composite bone cement[J].Journal of Zhejiang Sci-Tech University,2026,55-56(自科五):605-615.
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骨碎补总黄酮/贻贝粘蛋白复合骨水泥的制备及其促骨缺损修复作用研究()

浙江理工大学学报[ISSN:1673-3851/CN:33-1338/TS]

卷:
55-56
期数:
2026年自科第五期
页码:
605-615
栏目:
出版日期:
2026-09-20

文章信息/Info

Title:
Accelerating bone defect repair with total flavonoids of Rhizoma Drynariae and mussel adhesive protein-composite bone cement
文章编号:
1673-3851(2026) 09-0605-11
作者:
孙悦婷; 江国华
浙江理工大学材料科学与工程学院 ,杭州 310018
Author(s):
SUN Yueting; JIANG Guohua
School of Materials Science& Engineering,Zhejiang Sci-Tech University, Hangzhou 310018, China
关键词:
骨缺损 ; 骨再生 ; 骨碎补总黄酮; 骨水泥; 贻贝粘蛋白
分类号:
R318.08
文献标志码:
A
摘要:
为克服传统骨水泥生物活性不足、载药易流失的问题 ,制备了负载骨碎补总黄酮(TFRD)与贻贝粘蛋白(MAP)的生物活性复合骨水泥 。采用 SEM、FTIR表征其物理化学性能 , 结合体外细胞实验与大鼠股骨缺损模型 ,通过 Micro-CT与骨计量学分析(如骨体积分数 BV/TV、骨小梁数量 Tb. N、骨小梁分离度 Tb. Sp) , 以及苏木精-伊红 (H&E) 、Masson三色染色和番红-O/固绿(S-O/FG)组织学观察 ,综合评价其骨修复效果 。结果表明 :各组骨水泥的细胞存活率均高于 80% ,表现出良好的生物相容性 。其中 , 高剂量药物和蛋白联用组(TFRD15@PM)显著增强了细胞迁移能力(划痕面积率达 67%) ;体内实验也证实该组修复效果最佳 ,Micro-CT与组织学评估显示其 BV/TV (57%)及 Tb. N等骨计量学指标显著优于其他组(P<0.05) ,缺损区可见大量新生骨与成熟胶原纤维 ,界面结合紧密 。研究表明 ,TFRD与 MAP的引入将生物惰性骨水泥成功转变为具有生物活性和生物整合能力的骨再生平台 ,显著提升了其对骨缺损的修复效能 ,为新型骨缺损修复材料研究提供了实验依据。

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期 : 2025-11-19 网络出版日期 : 2026-04-29作者简介 : 孙悦婷(2001— ) ,女 ,陕西铜川人 ,硕士研究生 ,主要从事生物医用材料方面的研究。通信作者: 江国华,E-mail:ghjiang_cn@zstu. edu. cn
更新日期/Last Update: 2026-09-21