|本期目录/Table of Contents|

[1]饶梦,李王丹,刘晨光.阿瑞匹坦在恶性肿瘤治疗中的研究进展[J].浙江理工大学学报,2026,55-56(自科四):537-548.
 RAO Meng,LIWangdan,LIUChenguang.Research progress on aprepitant in the reatment of malignant tumors[J].Journal of Zhejiang Sci-Tech University,2026,55-56(自科四):537-548.
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阿瑞匹坦在恶性肿瘤治疗中的研究进展()

浙江理工大学学报[ISSN:1673-3851/CN:33-1338/TS]

卷:
55-56
期数:
2026年自科第四期
页码:
537-548
栏目:
出版日期:
2026-07-10

文章信息/Info

Title:
Research progress on aprepitant in the reatment of malignant tumors
文章编号:
1673-3851(2026) 07-0537-12
作者:
饶梦李王丹刘晨光
浙江理工大学生命科学与医药学院 ,杭州 310018
Author(s):
RAO MengLIWangdanLIUChenguang
College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China
关键词:
阿瑞匹坦NK-1RP物质 恶性肿瘤 靶向治疗
分类号:
R730.53
文献标志码:
A
摘要:
阿瑞匹坦作为神经激肽受体-1(Neurokinin1 receptor, NK-1R)的高选择性拮抗剂 , 目前已在临床广泛应用于预防化疗所致恶心呕吐 。近年来研究发现 ,NK-1R及其内源性配体 P物质(SubstanceP, SP)在多种恶性肿瘤中异常表达与活化 ,参与调控细胞增殖、凋亡、侵袭及转移等关键生物学过程 。 阿瑞匹坦除了传统的止吐应用外 ,其在抗肿瘤领域的潜在价值正日益受到关注 。总结 SP/NK-1R信号通路在肿瘤发生发展中的核心作用 , 归纳了 阿瑞匹坦在肺癌、结直肠癌、肝癌、胃癌、食管癌、乳腺癌及甲状腺癌等多种实体瘤中 ,通过调控 PI3K/AKT/mTOR与MAPK/ERK等关键通路 ,发挥抑制肿瘤增殖、诱导细胞死亡及阻滞转移的相关分子机制 。该综述聚焦阿瑞匹坦在“老药新用”策略下由止吐适应证向肿瘤治疗领域拓展过程中的现存挑战与未来研究方向 ,重点解析其实现抗肿瘤效应的关键转化路径 , 旨在为后续临床开发及作用机制研究提供理论支撑与创新视角。

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备注/Memo

备注/Memo:
基金项目 : 浙江理工大学科研启动项目(21042289-Y)收稿日期 : 2026-02-20 网络出版日期 : 2026-05-08
作者简介 : 饶 梦 (2000— ) ,女 ,安徽池州人 ,硕士研究生 ,主要从事抗肿瘤药物方面的研究。通信作者: 刘晨光,E-mail:cgliu@zstu. edu. cn0 引 言
更新日期/Last Update: 2026-07-05