|本期目录/Table of Contents|

[1]徐一涵,张坤义,舒超,等.征透明质酸/聚乙烯醇聚合物微针的制备及性能表征[J].浙江理工大学学报,2026,55-56(自科四):375-386.
 XUYihan,ZHANGKunyi,SHUChao,et al.Preparation and performance characterization of hyaluronic acid/Polyvinyl alcohol polymer microneedles[J].Journal of Zhejiang Sci-Tech University,2026,55-56(自科四):375-386.
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征透明质酸/聚乙烯醇聚合物微针的制备及性能表征()

浙江理工大学学报[ISSN:1673-3851/CN:33-1338/TS]

卷:
55-56
期数:
2026年自科第四期
页码:
375-386
栏目:
出版日期:
2026-07-10

文章信息/Info

Title:
Preparation and performance characterization of hyaluronic acid/
Polyvinyl alcohol polymer microneedles
文章编号:
1673-3851(2026) 07-0375-引文格式:徐一涵 ,张坤义
作者:
徐一涵张坤义舒超丁新波祝国成刘涛
浙江理工大学纺织科学与工程学院(国际丝绸学院) ,杭州 310018
Author(s):
XUYihanZHANGKunyiSHUChaoDINGXinboZHUGuochengLIUTao
College of Textile Scienceand Engineering(International Institute of Silk) , ZhejiangSci-Tech University, Hangzhou 310018, China
关键词:
聚合物微针 透明质酸 聚乙烯醇 抗菌性能 药物释放12
分类号:
TQ325;TQ320.63
文献标志码:
A
摘要:
为探究透明质酸(Hyaluronicacid,HA)/聚乙烯醇(Polyvinylalcohol,PVA)复合溶液用以制备聚合微针(Microneedles,MNs)的可行性 ,通过微模法配制不同质量分数(6%、8%、10%和 14%)的 HA/PVA复合溶将其注入聚二 甲基硅氧烷(PDMS)模具 , 以制备透明质酸/聚乙烯醇微针(HA/PVAMNs) ,探究不同HA/PVA复溶液质量分数下 HA/PVA MNs的微观形貌、溶胀行为、压缩性能及其体外皮肤刺入能力 ;在此基础上 , 以姜黄NsA/ A/A/(Curcumin,Cur)为药物实现 HA/PVAMNs对姜黄素的可控释放 ,并采用平板计数法评估载药后 HA/PVA M的抗菌性能 。结果表明 : 随着 HA/PVA复合溶液质量分数的不断升高 ,质量分数 14%的 HA/PVA微针(14H学 高PVAMNs)的压缩应力可增加至 0.77N/针 ,其皮肤刺入率可达99% ;随着磷酸盐缓冲液中姜黄素的不断释放 ,HPVAMNs的体外药物释放率随 HA/PVA复合溶液质量分数的提高而呈现逐减的趋势 ,释放行为遵循一阶动力模型 ,其中 6HA/PVAMNs的药物释放率最高 ,达81.48% ; 当 HA/PVAMNs抗菌质量浓度为 80mg/mL时 ,HPVAMNs对金黄色葡萄球菌与大肠埃希菌的体外抗菌率分别为 85.20%和 68.50% 。该研究为制备复合可溶性聚物微针提供了新的方法和实验依据。

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备注/Memo

备注/Memo:
收稿日期 : 2025-11-05 网络出版日期 : 2026-03-30基金项目 : 浙江省“尖兵”“领雁”研发攻关计划项目(2023C1194) ; 国家自然科学基金项目(31900964)作者简介 : 徐一涵(2001 ) ,女 ,江苏南通人 ,硕士研究生 ,主要从事聚合物微针及生物材料方面的研究。通信作者: 刘 涛,E-mail:39851007@qq. com
更新日期/Last Update: 2026-07-05