|本期目录/Table of Contents|

[1]金贾力,徐晨,李云泽,等.慢性疼痛性别差异的病理机制及应对策略[J].浙江理工大学学报,2025,53-54(自科一):130-138.
　JIN Jiali,XU Chen,LI Yunze,et al.Pathological mechanisms and coping strategies of gender differences in chronic pain[J].Journal of Zhejiang Sci-Tech University,2025,53-54(自科一):130-138.
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慢性疼痛性别差异的病理机制及应对策略()
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浙江理工大学学报[ISSN:1673-3851/CN:33-1338/TS]

卷:
第53-54卷
期数:
2025年自科第一期
页码:
130-138
栏目:
出版日期:
2025-01-10

文章信息/Info

Title:
Pathological mechanisms and coping strategies of gender differences in chronic pain
文章编号:
1673-3851 (2025) 01-0130-09
作者:
金贾力; 徐晨; 李云泽; 冯智英
1.浙江大学医学院附属第一医院疼痛科，杭州 310003；2.海宁市中心医院麻醉科，浙江嘉兴  314400；3.浙江理工大学生命科学与医药学院，杭州 310018
Author(s):
JIN Jiali;  XU Chen;  LI Yunze;  FENG Zhiying
1.Department of Pain Management, The First Affiliated Hospital, Zhejiang University  School of Medicine, Hangzhou 310003, China; 2.Department of  Anesthesiology, Haining Central Hospital, Jiaxing 314400,China; 3.College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China
关键词:
疼痛; 性别差异; 慢性疼痛; 病理机制; 性激素
分类号:
Q986
文献标志码:
A
摘要:
慢性疼痛往往造成个人、家庭及社会的沉重负担。在大多数慢性疼痛中，女性患病率比男性更高，但长期以来慢性疼痛存在的性别差异未受到足够重视。随着大数据时代的到来，疼痛的性别差异逐渐引起科研人员及临床医生关注，正成为疼痛领域研究的新热点。慢性疼痛病理机制复杂，临床治疗难度大，应当实施个体化治疗，必需考虑疼痛的性别差异。总结近二十年该领域的研究成果，从性激素、细胞等层面探讨疼痛性别差异的病理机制，并提出应对策略，以期为慢性疼痛性别差异相关研究提供方向，为临床医生制定更精准的诊疗策略提供理论参考依据

参考文献/References:

［ 1 ］ Raja S N, Carr D B, Cohen M, et al. The revised International Association for the Study of Pain definition of pain: Concepts, challenges, and compromises ［ J ］ . Pain, 2020, 161(9): 1976 - 1982.

［2］Gaskin D J, Richard P. The economic costs of pain in the United States［J］. The Journal of Pain, 2012, 13(8): 715-724.

［3］Shupler M S, Kramer J K, Cragg J J, et al. Pan-canadian estimates of chronic pain prevalence from 2000 to 2014: A repeated cross-sectional survey analysis［J］. The Journal of Pain, 2019,20(5): 557-565.

［4］van Hecke O, Austin S K, Khan R A, et al. Neuropathic pain in the general population: a systematic review of epidemiological studies［J］. Pain, 2014, 155(4): 654-662.

［5］Osborne N R, Davis K D. Sex and gender differences in pain［M］∥International Review of Neurobiology. Amsterdam: Elsevier, 2022: 277-307.

［6］Bale T L, Epperson C N. Sex as a biological variable: Who, what, when, why, and how［J］. Neuropsychopharmacology, 2017, 42(2): 386-396.

［7］Mogil J S. Qualitative sex differences in pain processing: Emerging evidence of a biased literature［J］. Nature Reviews Neuroscience, 2020, 21(7): 353-365.

［8］Bartley E J, Fillingim R B. Sex differences in pain: A brief review of clinical and experimental findings［J］. British Journal of Anaesthesia, 2013, 111(1): 52-58.

［9］Edvinsson L. New therapeutic target in primary headaches-blocking the CGRP receptor［J］. Expert Opinion on Therapeutic Targets, 2003, 7(3): 377-383.

［10］Queme L F, Jankowski M P. Sex differences and mechanisms of muscle pain［J］. Current Opinion in Physiology, 2019, 11: 1-6.

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备注/Memo

备注/Memo:
收稿日期： 2024-06-20
网络出版日期：2024-09-13
基金项目： 国家自然科学基金项目（82271239）；浙江省自然科学基金项目（LQ22H090022）
作者简介： 金贾力（1992—），男，杭州人，主治医师，硕士研究生，主要从事慢性疼痛诊疗方面的研究
通信作者： 冯智英，E-mail：fzy1972@zju.edu.cn
更新日期/Last Update: 2025-01-07