[1]林超,袁于民.PEG的分散性及结构对PEG化胶束在BSA溶液中稳定性的影响[J].浙江理工大学学报,2024,51-52(自科六):743-752.
LIN Chao,YUAN Yumin.Effect of PEG dispersity and structure on the stability of PEG micelles in BSA solutions[J].Journal of Zhejiang Sci-Tech University,2024,51-52(自科六):743-752.
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PEG的分散性及结构对PEG化胶束在BSA溶液中稳定性的影响()
LIN Chao,YUAN Yumin.Effect of PEG dispersity and structure on the stability of PEG micelles in BSA solutions[J].Journal of Zhejiang Sci-Tech University,2024,51-52(自科六):743-752.
浙江理工大学学报[ISSN:1673-3851/CN:33-1338/TS]
- 卷:
- 第51-52卷
- 期数:
- 2024年自科第六期
- 页码:
- 743-752
- 栏目:
- 出版日期:
- 2024-11-20
文章信息/Info
- Title:
- Effect of PEG dispersity and structure on the stability of PEG micelles in BSA solutions
- 分类号:
- TQ432-2
- 文献标志码:
- A
- 摘要:
- 聚乙二醇（Polyethylene glycol, PEG）化胶束在体外的稳定性是其作为纳米药物载体的重要参考指标。将不同分散性和结构的PEG，与十八烷酸、十四烷酸、1,2-二硬脂酸3-磷脂酰乙醇、胆固醇、维生素E琥珀酸酯、N,N双十四烷基胺和抗癌药物紫杉醇等合成一系列两亲性聚合物；分析在相同疏水段的条件下，PEG的分散性和结构对其胶束临界胶束浓度（Critical micelle concentration, CMC）、粒径以及在牛血清白蛋白（BSA）溶液中的稳定性的影响。结果显示：PEG的分散性对线形PEG化胶束的CMC和粒径影响不明显，分支结构的PEG化胶束在CMC和粒径上均显著小于线形PEG化胶束；在BSA溶液中，分支结构的PEG化胶束的稳定性显著优于线形单分散的，多分散PEG化胶束的稳定性最差，PEG结构和分散性影响胶束的体外稳定性。该文结果为开发单分散PEG化胶束的药物递送系统提供了重要的理论依据。
参考文献/References:
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备注/Memo
- 备注/Memo:
-
收稿日期： 2024-03-08
网络出版日期：2024-05-08
作者简介： 林超（1995—），男，江苏盱眙人，硕士研究生，主要从事两亲性胶束方面的研究
通信作者： 袁于民，E-mail：yyuan@biomatrik.com
