|本期目录/Table of Contents|

[1]陈思颖,谢番,赵瑞波,等.仿生矿化透明质酸钠复合材料的制备及其性能分析[J].浙江理工大学学报,2024,51-52(自科三):292-299.
　CHEN Siying,XIE Fan,ZHAO Ruibo,et al.Preparation of biomimetic mineralized sodium hyaluronate composites and the analysis of their properties[J].Journal of Zhejiang Sci-Tech University,2024,51-52(自科三):292-299.
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仿生矿化透明质酸钠复合材料的制备及其性能分析()
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浙江理工大学学报[ISSN:1673-3851/CN:33-1338/TS]

卷:
第51-52卷
期数:
2024年自科第三期
页码:
292-299
栏目:
出版日期:
2024-05-10

文章信息/Info

Title:
Preparation of biomimetic mineralized sodium hyaluronate composites and the analysis of their properties
文章编号:
1673-3851 (2024) 05-0292-08
作者:
陈思颖; 谢番; 赵瑞波; 孔祥东
浙江理工大学材料科学与工程学院，杭州 310018
Author(s):
CHEN Siying;  XIE Fan;  ZHAO Ruibo;  KONG Xiangdong
School of Materials Science & Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China
关键词:
仿生矿化; 透明质酸钠; 磷酸钙寡聚体; 复合材料; 力学性能
分类号:
TB33
文献标志码:
A
摘要:
为了提升透明质酸钠（Sodium hyaluronate, SH）的力学性能，采用仿生矿化方法，将磷酸钙寡聚体（Calcium phosphate oligomers, CPO）与SH复合形成透明质酸钠复合材料（SH-CPO），对SH-CPO的形貌、结构、流变学特性及压缩性能进行了测试与表征。结果表明：SH不仅与CPO具有良好的相互作用，反应后能形成内部结构连续的复合材料，还能诱导CPO发生从无定形到结晶相的转变；在SH与CPO的质量比为1∶1~1∶10范围内，随着CPO投料比例的增加，制备的SH CPO复合材料的黏度得到提升，压缩强度可达到53.5 MPa。该研究制备的SH-CPO复合材料具有良好的力学性能，在生物医学材料领域中具有良好的应用潜力。

参考文献/References:

［1］Chae J J, Jung J H, Zhu W, et al. Drug-free, nonsurgical reduction of intraocular pressure for four months after suprachoroidal injection of hyaluronic acid hydrogel［J］. Advanced Science, 2021, 8(2): 2001908.
［2］Raia N R, Jia D, Ghezzi C E, et al. Characterization of silk-hyaluronic acid composite hydrogels towards vitreous humor substitutes［J］. Biomaterials, 2020, 233: 119729.
［3］Cai Z X, Tang Y M, Wei Y, et al. Physically cross-linked hyaluronan-based ultrasoft cryogel prepared by freeze-thaw technique as a barrier for prevention of postoperative adhesions［J］. Biomacromolecules, 2021, 22(12): 4967-4979.
［4］Li Z Y, Liu L X, Chen Y M. Dual dynamically crosslinked thermosensitive hydrogel with self-fixing as a postoperative anti-adhesion barrier［J］. Acta Biomaterialia, 2020, 110: 119-128.
［5］Jin Y J, Koh R H, Kim S H, et al. Injectable anti-inflammatory hyaluronic acid hydrogel for osteoarthritic cartilage repair［J］. Materials Science and Engineering: C-Materials for Biological Applications, 2020, 115: 111096.
［6］Galarraga J H, Locke R C, Witherel C E, et al. Fabrication of MSC-laden composites of hyaluronic acid hydrogels reinforced with MEW scaffolds for cartilage repair［J］. Biofabrication, 2022, 14(1): 041406.
［7］Burdick J A, Prestwich G D. Hyaluronic acid hydrogels for biomedical applications［J］. Advanced Materials, 2011, 23(12): 41-56.
［8］Khanlari A, Schulteis J E, Suekama T C, et al. Designing crosslinked hyaluronic acid hydrogels with tunable mechanical properties for biomedical applications［J］. Journal of Applied Polymer Science, 2015, 132(22): 42009.
［9］Crescenzi V, Francescangeli A, Taglienti A, et al. Synthesis and partial characterization of hydrogels obtained via glutaraldehyde crosslinking of acetylated chitosan and of hyaluronan derivatives［J］. Biomacromolecules, 2003, 4(4): 1045-1054.
［10］Choi S C, Yoo M A, Lee S Y, et al. Modulation of biomechanical properties of hyaluronic acid hydrogels by crosslinking agents［J］. Journal of Biomedical Materials Research Part A, 2015, 103(9): 3072-3080.

备注/Memo

备注/Memo:
收稿日期： 2023-09-01
网络出版日期：2023-12-06
基金项目： 国家自然科学基金项目(51902289)；浙江省自然科学基金项目(LQ19E020010)
作者简介： 陈思颖(1997—)，女，湖北武汉人，硕士研究生，主要从事生物医用材料方面的研究
通信作者： 赵瑞波，E-mail：rzhao@zstu.edu.cn
更新日期/Last Update: 2024-06-19