|本期目录/Table of Contents|

[1]贺蓉,刘涛,丁新波,等.聚多巴胺涂覆Cu-MBG的生物活性及抗菌性能研究[J].浙江理工大学学报,2023,49-50(自科四):508-515.
 HE Rong,LIU Tao,DING Xinbo,et al.Study on the biological activity and antibacterial properties of  polydopamine-modified Cu-MBG[J].Journal of Zhejiang Sci-Tech University,2023,49-50(自科四):508-515.
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聚多巴胺涂覆Cu-MBG的生物活性及抗菌性能研究()
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浙江理工大学学报[ISSN:1673-3851/CN:33-1338/TS]

卷:
第49-50卷
期数:
2023年自科第四期
页码:
508-515
栏目:
出版日期:
2023-09-10

文章信息/Info

Title:
Study on the biological activity and antibacterial properties of  polydopamine-modified Cu-MBG
文章编号:
1673-3851 (2023) 07-0508-08
作者:
贺蓉刘涛丁新波仇巧华朱灵奇
浙江理工大学纺织科学与工程学院(国际丝绸学院),杭州 310018
Author(s):
HE Rong LIU Tao DING Xinbo QIU Qiaohua ZHU Lingqi
College of Textile Science and Engineering (International Institute of Silk), Zhejiang Sci-Tech University, Hangzhou 310018, China
关键词:
生物活性玻璃聚多巴胺生物活性抗菌性能
分类号:
TB381
文献标志码:
A
摘要:
为了获得适用于治疗骨髓炎骨组织缺损及修复的生物材料,受贻贝蛋白的强黏附性能的启发,以掺铜的生物玻璃(Cu MBG)纳米颗粒为基底,在Cu MBG表面涂覆聚多巴胺(PDA),得到Cu MBG@PDA;对PDA涂覆前后的Cu MBG纳米颗粒的形貌和结构进行表征,分析其亲水性、体外生物活性及抗菌性能。结果表明:经过PDA涂覆的Cu MBG@PDA的水接触角减小到44.31°,亲水性能明显提高;在体外模拟体液(SBF)中浸泡之后,Cu MBG@PDA样品比Cu MBG有着更快的羟基磷灰石形成能力;经过PDA涂覆的Cu MBG@PDA具有优异的抗菌性能,对金黄色葡萄球菌(Staphylococcus aureus, S. aureus)和大肠杆菌(Escherichia coli, E.coli)的抑制率都提高到99.90%以上。经过PDA涂覆的Cu MBG@PDA具有更优异的亲水性、体外生物活性及抗菌性能,有望应用于慢性骨髓炎导致的骨组织缺损及修复方面的治疗。

参考文献/References:

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9 Taskin M B, Xu R D, Gregersen H, et al. Three - dimensional polydopamine functionalized coiled microfibrous scaffolds enhance human mesenchymal stem cells colonization and mild myofibroblastic differentiation J . ACS Applied Materials & Interfaces, 2016, 8(25): 15864 - 15873.

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备注/Memo

备注/Memo:
收稿日期: 2022-12-13
网络出版日期:2023-03-01
基金项目: 国家自然科学基金项目(31900964)
作者简介: 贺蓉(1997-),女,山西临汾人,硕士研究生,主要从事生物纳米材料方面的研究
通信作者: 刘涛,E-mail:39851007@qq.com
更新日期/Last Update: 2023-09-11