|本期目录/Table of Contents|

[1]刘涵,尹子楚,蔡玉荣,等.丝素蛋白/多巴胺医用粘合剂的制备及其性能[J].浙江理工大学学报,2020,43-44(自科三):308-314.
　LIU Han,YIN Zichu,CAI Yurong,et al.Preparation and properties of silk fibroin/dopamine medical adhesive[J].Journal of Zhejiang Sci-Tech University,2020,43-44(自科三):308-314.
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丝素蛋白/多巴胺医用粘合剂的制备及其性能()
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浙江理工大学学报[ISSN:1673-3851/CN:33-1338/TS]

卷:
第43-44卷
期数:
2020年自科三期
页码:
308-314
栏目:
出版日期:
2020-06-09

文章信息/Info

Title:
Preparation and properties of silk fibroin/dopamine medical adhesive
文章编号:
1673-3851 (2020) 05-0308-07
作者:
刘涵; 尹子楚; 蔡玉荣; 姚菊明
浙江理工大学材料科学与工程学院，杭州 310018
Author(s):
LIU Han;  YIN Zichu;  CAI Yurong;  YAO Juming
School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China
关键词:
丝素蛋白; 多巴胺; 京尼平; 生物粘合剂; 共价交联
分类号:
TB34
文献标志码:
A
摘要:
为了获得兼具良好生物相容性及较强粘合强度的生物医用粘合剂，以丝素蛋白为基质和NHS/EDC为交联剂，在丝素蛋白上接枝多巴胺；采用京尼平对丝蛋白多巴胺材料进行共价交联，从而制得了丝素蛋白/多巴胺医用粘合剂；通过正交实验的方法，分析多因素对粘合剂粘合强度的影响，优化制备工艺。结果表明：丝素蛋白浓度、反应时间、NHS/EDC的使用量、多巴胺的添加量以及京尼平的用量均可影响所得粘合剂的粘合强度。当丝素蛋白浓度为12%、多巴胺与丝素蛋白羧基摩尔比为1∶6，以及京尼平与丝素蛋白氨基摩尔比为2∶1时，所制得的粘合剂性能最佳；优化条件下制得的粘合剂在37 ℃条件下具有最高的粘合强度，且此强度随使用时间的增长而增大，12 h时可达到(181 49±42 82) kPa，是临床上正在使用的纤维蛋白胶的粘合强度的18倍。制备的粘合剂具有较好的可降解性，在临床上具有一定的应用前景。

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期：2019-10-24
网络出版日期：2020-01-04
基金项目：国家自然科学基金项目(51672251)；浙江省新苗人才计划(2019R406060)
作者简介：刘涵（1995-），女，广东汕头人，硕士研究生，主要从事生物医用材料方面的研究
通信作者：姚菊明，E-mail：yaoj@zstu.edu.cn
更新日期/Last Update: 2020-06-10