|本期目录/Table of Contents|

[1]钟奇伟,蔡玉荣.球形碳酸钙/羟基磷灰石的制备及药物控释[J].浙江理工大学学报,2016,35-36(自科5):474-480.
　ZHONG Qiwei,CAI Yurong.Preparation of CaCO 3 and Hydroxyapatite Microsphere and  Its Potential Application in Drug Controlled Release[J].Journal of Zhejiang Sci-Tech University,2016,35-36(自科5):474-480.
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球形碳酸钙/羟基磷灰石的制备及药物控释()
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浙江理工大学学报[ISSN:1673-3851/CN:33-1338/TS]

卷:
第35-36卷
期数:
2016年自科5期
页码:
474-480
栏目:
出版日期:
2016-09-10

文章信息/Info

Title:
Preparation of CaCO 3 and Hydroxyapatite Microsphere and  Its Potential Application in Drug Controlled Release
文章编号:
1673-3851 (2016) 05-0685-06
作者:
钟奇伟; 蔡玉荣
浙江理工大学材料与纺织学院，杭州 310018
Author(s):
ZHONG Qiwei;  CAI Yurong
College of Materials and Textiles, Zhejiang Sci-Tech University, Hangzhou 310018, China
关键词:
碳酸钙; 羟基磷灰石; 药物载体; 负载及释放
分类号:
TB34
文献标志码:
A
摘要:
丝胶蛋白调控得到尺寸均一的球形碳酸钙颗粒，并以此为硬模板，辅以水热，制备羟基磷灰石微球。以盐酸阿霉素为药物模型，用合成的碳酸钙、羟基磷灰石球形颗粒对其分别进行有效负载和可控释放研究，并用体外实验评价载药颗粒对共培养细胞的影响。用场发射扫描电子显微镜(FE-SEM)、傅里叶红外吸收光谱(FT-IR)、X射线粉末衍射(XRD)、紫外分光光度计和荧光显微镜等对样品进行了检测。结果表明：丝胶有利于碳酸钙球霰石相的稳定，同时通过离子交换反应可将碳酸钙转化为羟基磷灰石，碳酸钙和羟基磷灰石对盐酸阿霉素最佳负载浓度分别为8 μg/mL和10 μg/mL，羟基磷灰石对药物的控制释放能力更强。体外Huh7肝癌细胞实验表明载药颗粒对细胞的增殖有明显抑制作用，证明所制颗粒的药物负载和释放功能。

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期： 2015-11-16
基金项目： 国家自然科学基金项目(51202219)；浙江省自然科学基金项目(LY16E020013)
作者简介： 钟奇伟 (1990-)，男，浙江湖州人，硕士研究生，主要从事生物材料方面的研究
通信作者： 蔡玉荣，E-mail: caiyr@zstu.edu.cn
更新日期/Last Update: 2016-10-12