|本期目录/Table of Contents|

[1]王青,傅枭男,洪祝平,等.乳腺癌中SRA1基因表达调控的生物信息学分析[J].浙江理工大学学报,2016,35-36(自科2):283-289.
　WANG Qing,FU Xiaonan,HONG Zhuping,et al.Bioinformatic Analysis of  SRA 1 Gene in Breast Cancer[J].Journal of Zhejiang Sci-Tech University,2016,35-36(自科2):283-289.
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乳腺癌中SRA1基因表达调控的生物信息学分析()
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浙江理工大学学报[ISSN:1673-3851/CN:33-1338/TS]

卷:
第35-36卷
期数:
2016年自科2期
页码:
283-289
栏目:
出版日期:
2016-03-10

文章信息/Info

Title:
Bioinformatic Analysis of  SRA 1 Gene in Breast Cancer
文章编号:
1673-3851 (2016) 04-0283-07
作者:
王青; 傅枭男 ; 洪祝平 ; 张玉涵 ; 郑春红;  王语嫣; 丁先锋
1.浙江理工大学生命科学学院生物工程研究所，杭州 310018;2.浙江经贸职业技术学院应用工程系，杭州 310018
Author(s):
WANG Qing;  FU Xiaonan;  HONG Zhuping;  ZHANG Yuhan; ZHENG Chunhong;  WANG Yuyan;  DING Xianfeng
1.Institute of Bioengineerning , College of Life Sciences, Zhejiang Sci-Tech  University, Hangzhou 310018, China; 2. Department of Application Engineering, Zhejiang Economic & Trade Polytechnic, Hangzhou 310018, China
关键词:
乳腺癌; 类固醇受体激活物; lncRNA SRA1miRNAsmRNAs; 生物信息学
分类号:
Q786
文献标志码:
A
摘要:
分析类固醇受体RNA激活物（steroid receptor RNA activator, SRA1）以长链非编码RNA形式(lncRNA SRA1)和蛋白质形式(SRA1蛋白)在乳腺癌中的分子调控网络。运用RegRNA、Targetscan、MicroCosm Targets、PicTar软件和HMDD、DAVID在线数据库，预测lncRNA SRA1与microRNA及下游靶基因间的多种调控途径，对靶基因进行功能富集分析，绘制lncRNA SRA1的核心调控网络图。同时运用TCGA数据库、string软件预测分析与SRA1蛋白相互作用的蛋白质。发现lncRNA SRA1上存在hsalet7b、 hsalet7c、 hsalet7g、hsalet7i、hasmiR92、hasmiR103、hasmiR194、hasmiR874、hasmiR141、hasmiR146a、hasmiR661这11个与乳腺癌相关microRNA的可能结合位点，从而调节下游230个靶基因，构建了lncRNA SRA1miRNAsmRNAs调控网络，提示lncRNA SRA1可能参与基因转录调控、生物合成、MAPK、癌症相关通路、紧密连接等信号通路。并且发现SRA1蛋白和DDX17、ESR1、NCOA2、NCOA1、NRIP1等多种蛋白存在相互作用。对SRA1基因调控网络的生物信息学分析有助于理解其在乳腺癌发生发展过程中的分子机制。

参考文献/References:

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相似文献/References:

[1]郭鹏飞,贺平安.乳腺癌癌症干细胞的特异基因识别[J].浙江理工大学学报,2017,37-38(自科3):451.
　GUO Pengfei,HE Pingan.Identification of Specific Genes of Cancer Stem Cells of Breast Cancer[J].Journal of Zhejiang Sci-Tech University,2017,37-38(自科2):451.

备注/Memo

备注/Memo:
收稿日期： 2015-07-30
基金项目： 国家自然科学基金项目（11105121）；浙江省自然科学基金项目（LY15C050002）；浙江省创新团队项目（2014R406078）；浙江经贸职业技术学院大学生创新项目（20140421）
作者简介： 王青(1991-)，女，江苏盐城人，硕士研究生，主要从事肿瘤非编码RNA方面的研究
通信作者： 丁先锋，E-mail: xfding@zstu.edu.cn
更新日期/Last Update: 2016-06-02