|本期目录/Table of Contents|

[1]江银枝,高小龙,李文静. 艾沙拉唑的合成和分子力场模拟研究[J].浙江理工大学学报,2012,29(01):146-149.
 JIANG Yin\|zhi,GAO Xiao\|long,LI Wen\|jing.Study on the Synthesis Properties of Esaprazole[J].Journal of Zhejiang Sci-Tech University,2012,29(01):146-149.
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 艾沙拉唑的合成和分子力场模拟研究()
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浙江理工大学学报[ISSN:1673-3851/CN:33-1338/TS]

卷:
第29卷
期数:
2012年01期
页码:
146-149
栏目:
(自科)生物与生命科学
出版日期:
2012-02-28

文章信息/Info

Title:
Study on the Synthesis Properties of Esaprazole
文章编号:
16733851 (2012) 01014604
作者:
 江银枝 高小龙 李文静
 浙江理工大学化学系, 杭州 310018
Author(s):
 JIANG Yin\|zhi GAO Xiao\|long LI Wen\|jing
 Department of Chemistry, Zhejiang Sci\|Tech University, Hangzhou 310018, China
关键词:
 艾沙拉唑 合成 表征 正交优化 分子力场
分类号:
O622.5
文献标志码:
A
摘要:
    研究了艾沙拉唑(Ⅱ)的合成和分子力场。以环己胺和氯乙酰氯为原料合成了N\|环己基\|2\|氯乙酰胺(Ⅰ)。再以Ⅰ与哌嗪为原料合成了Ⅱ。采用三因素三水平的正交法对Ⅰ的合成条件进行了优化,发现合成Ⅰ的最优条件为:n环己胺∶n氯乙酰氯∶nNaOH =1∶1.5∶3,反应温度为15℃;最优条件下平行实验的RSD=0.42%。采用重结晶法进行了Ⅱ的纯化,〖JP2〗与已有文献相比,易于工业化。利用软件FieldTemplatre2.2.0和FieldAlign2.1进行了Ⅱ的分子力场计算,发现其与苯并咪唑类质子泵抑制剂与靶体作用的分子力场接近,显示出Ⅱ具有质子泵抑制活性的潜力。

参考文献/References:

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备注/Memo

备注/Memo:
 收稿日期: 2010-07-05
基金项目: 国家自然科学基金项目(20901067);浙江省自然科学基金项目(Y4080342)
作者简介: 江银枝(1973-),女,湖北鄂州人,博士,副教授,从事有机化学、配位化学、药物化学的教学与科研。
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