|本期目录/Table of Contents|

[1]朱雪松,童再再.UCNP@mSiO2纳米载体及其近红外光触发的药物可控释放研究[J].浙江理工大学学报,2022,47-48(自科六):900-907.
　ZHU Xuesong,TONG Zaizai.UCNP@mSiO2 nanocarriers and their controlled drug release triggered by near infrared light[J].Journal of Zhejiang Sci-Tech University,2022,47-48(自科六):900-907.
点击复制

UCNP@mSiO2纳米载体及其近红外光触发的药物可控释放研究()
分享到：

浙江理工大学学报[ISSN:1673-3851/CN:33-1338/TS]

卷:
第47-48卷
期数:
2022年自科第六期
页码:
900-907
栏目:
出版日期:
2022-11-10

文章信息/Info

Title:
UCNP@mSiO2 nanocarriers and their controlled drug release triggered by near infrared light
文章编号:
1673-3851 (2022) 11-0900-08
作者:
朱雪松; 童再再
浙江理工大学材料与科学工程学院，杭州 310018
Author(s):
ZHU Xuesong;  TONG Zaizai
School of Materials Science & Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China
关键词:
上转换纳米粒子; 近红外光; 偶氮苯; 介孔二氧化硅; 可控释放
分类号:
TB381
文献标志码:
A
摘要:
为解决纳米载药体系在药物传递过程中不可控释放的问题，设计了一种近红外光（NIR）触发的光控药物释放体系。首先通过合成上转换纳米粒子（UCNPs），并在其表面包覆介孔二氧化硅（mSiO2），得到UCNP@mSiO2；然后将偶氮苯（AZO）分子接枝到UCNP@mSiO2表面，并在mSiO2的介孔上负载阿霉素（DOX）；最后加入环糊精（β CD），得到纳米载药体系DOX UCNP@mSiO 2@AZO@β CD。对纳米载药体系的形貌和结构进行表征，并研究其在NIR照射下的药物可控释放行为。结果表明：药物释放速率随NIR光照强度的增加而增加，而在无NIR照射时药物基本不释放；细胞毒性实验证实纳米载药体系在无NIR照射时具有良好的生物相容性，而在NIR照射后显示出高的细胞毒性，表明负载的DOX在NIR照射下被释放并实现了杀死癌细胞的目的。该纳米载药体系具有优良的NIR触发的光控药物释放行为，在药物递送领域具有一定的应用价值。

参考文献/References:

［ 1 ］ Lei Q, Qiu W X, Hu J J, et al. Multifunctional mesoporous silica nanoparticles with thermal-responsive gatekeeper for NIR light-triggered chemo/photothermal-therapy ［ J ］ . Small, 2016, 12(31): 4286-4298.

［2］Xiong X, Xu Z, Huang H, et al. A NIR light triggered disintegratable nanoplatform for enhanced penetration and chemotherapy in deep tumor tissues［J］. Biomaterials, 2020, 245:119840.

［3］Wang F, Deng R, Wang J, et al. Tuning upconversion through energy migration in core-shell nanoparticles［J］. Nature Materials, 2011, 10(12): 968-973.

［4］Wang X, Liu X, Wang L, et al. Synthesis ofyolk-shell polymeric nanocapsules encapsulated with monodispersed upconversion nanoparticle for dual-responsive controlled drug release［J］. Macromolecules, 2018, 51(24): 10074-10082.

［5］Tang M, Zhu X, Zhang Y, et al. Near-infrared excited orthogonal emissive upconversion nanoparticles for imaging-guided on-demand therapy［J］. ACS Nano, 2019, 13(9): 10405-10418.

［6］Han R, Tang K, Hou Y, et al. Fabrication of core/shell/shell structure nanoparticle with anticancer drug and dual-photosensitizer co-loading for synergistic chemotherapy and photodynamic therapy［J］. Microporous and Mesoporous Materials, 2020, 297: 110049.

［7］Wang X, Liu C, LI Z, et al. Thermal and Photo dual-responsive core-shell polymeric nanocarriers with encapsulation of upconversion nanoparticles for controlled anticancer drug release［J］. The Journal of Physical Chemistry C, 2019, 123(16): 10658-10665.

［8］Yao X, Li M, Li B, et al. Tumor-targeted upconverting nanoplatform constructed by host-guest interaction for near-infrared-light-actuated synergistic photodynamic-/chemotherapy［J］. Chemical Engineering Journal, 2020, 390(15): 124516.

［9］Zhang Z, Jayakumar M K G, Shikha S, et al. Modularly assembled upconversion nanoparticles for orthogonally controlled cell imaging and drug delivery［J］. ACS Appl Mater Interfaces, 2020, 12(11): 12549-12556.

［10］Cui L, Zhang F, Wang Q, et al. NIR light responsive core-shell nanocontainers for drug delivery［J］. J Mater Chem B, 2015, 3(35): 7046-7054.

undefined

相似文献/References:

[1]吴杨龙,董余兵,傅雅琴.光驱动型聚多巴胺/水性环氧形状记忆复合材料[J].浙江理工大学学报,2020,43-44(自科二):173.
　WU Yanglong,DONG Yubing,FU Yaqin.Lightdriven polydopamine/waterborne epoxy shape memory composite[J].Journal of Zhejiang Sci-Tech University,2020,43-44(自科六):173.

备注/Memo

备注/Memo:
收稿日期： 2022-03-04
网络出版日期：2022-06-02
基金项目： 浙江省自然科学基金项目（LY20E030005）
作者简介： 朱雪松（1996-），男，安徽淮南人，硕士研究生，主要从事智能纳米材料方面的研究。
通信作者： 童再再，E-mail：tongzz@zstu.edu.cn
更新日期/Last Update: 2022-11-07