|本期目录/Table of Contents|

[1]尹子楚,林敏婕,程修文,等.ZnO基葡萄糖响应性药物载体的制备与性能[J].浙江理工大学学报,2021,45-46(自科五):581-587.
　YIN Zichu,LIN Minjie,CHENG Xiuwen,et al.Preparation and properties of ZnObased glucoseresponsive drug carrier[J].Journal of Zhejiang Sci-Tech University,2021,45-46(自科五):581-587.
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ZnO基葡萄糖响应性药物载体的制备与性能()
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浙江理工大学学报[ISSN:1673-3851/CN:33-1338/TS]

卷:
第45-46卷
期数:
2021年自科第五期
页码:
581-587
栏目:
出版日期:
2021-09-10

文章信息/Info

Title:
Preparation and properties of ZnObased glucoseresponsive drug carrier
文章编号:
1673-3851 (2021) 09-0581-07
作者:
尹子楚; 林敏婕; 程修文; 杨云聪; 蔡玉荣
浙江理工大学材料科学与工程学院，杭州 310018
Author(s):
YIN Zichu;  LIN Minjie;  CHENG Xiuwen;  YANG Yuncong;  CAI Yurong
School of Materials Science & Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China
关键词:
氧化锌; 苯硼酸; 葡萄糖响应; 药物载体
分类号:
TB33
文献标志码:
A
摘要:
采用溶剂热法制备氨基化的介孔ZnO纳米颗粒，通过酰胺化反应将经过EDC/NHS活化的4羧基苯硼酸（CPBA）结合到氨基化ZnO纳米颗粒上，并负载降糖药二甲双胍；利用苯硼酸能与邻二醇结合的原理，进一步在纳米颗粒表面修饰海藻酸钠（SA），得到具有葡萄糖响应性的SA/CPBA/ZnO药物载体；通过SEM、XRD、FTIR、氮气吸脱附法、Zeta电位等方式对氨基化ZnO、CPBA/ZnO、SA/CPBA/ZnO进行表征。结果表明：CPBA和SA成功结合到氨基化ZnO的表面；SA/CPBA/ZnO具有葡萄糖响应性，当葡萄糖浓度为4 mg/mL时，12 h内药物累计释放率为71-8%，比在1 mg/mL葡萄糖溶液中增加了26-4%，累计释放率在一定范围内与葡萄糖浓度正相关；SA/CPBA/ZnO具有良好的生物相容性，具备作为葡萄糖响应性药物递送体系载体的潜力。

参考文献/References:

［1］ 郑亚珍. 介孔纳米二氧化硅葡萄糖响应型胰岛素递送系统的研究［D］.郑州: 郑州大学, 2018：17-23.
［2］ Cho N H, Shaw J E, Karuranga S, et al. IDF diabetes atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045 ［J］. Diabetes Research and Clinical Practice, 2018, 138(2):271-281.
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［4］ Yang H, Sun X, Liu G, et al. Glucoseresponsive complex micelles for selfregulated release of insulin under physiological conditions ［J］. Soft Matter, 2013, 9(35): 8589-8599.
［5］ Kota S, Modi K, Satya Krishna S. Glycemic variability: Clinical implications ［J］. Indian Journal of Endocrinology and Metabolism, 2013, 17(4): 611-619.
［6］ Wu Q, Wang L, Yu H, et al. Organization of glucoseresponsive systems and their properties ［J］. Chemical Reviews, 2011, 111(12): 7855-7875.
［7］ Di J, Yu J, Ye Y, et al. Engineering synthetic insulinsecreting cells using hyaluronic acid microgels integrated with glucoseresponsive nanoparticles ［J］. Cellular and Molecular Bioengineering, 2015, 8(3): 445-454.
［8］ Zhao L, Xiao C, Ding J, et al. Competitive bindingaccelerated insulin release from a polypeptide nanogel for potential therapy of diabetes ［J］. Polymer Chemistry, 2015, 6(20): 3807-3815.
［9］ Li C, Huang F, Liu Y, et al. Nitrilotriacetic acidfunctionalized glucoseresponsive complex micelles for the efficient encapsulation and selfregulated release of insulin ［J］. Langmuir, 2018, 34(40): 12116-12125.
［10］ Hou L, Zheng Y, Wang Y, et al. Selfregulated carboxyphenylboronic acidmodified mesoporous silica nanoparticles with “touch switch” releasing property for insulin delivery ［J］. ACS Applied Materials & Interfaces, 2018, 10(26): 21927-21938.

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备注/Memo

备注/Memo:
收稿日期：2021-01-18
网络出版日期：2021-03-31
基金项目：浙江理工大学基本科研业务费项目(2019Y006)
作者简介：尹子楚(1996-)，男，浙江嵊州人，硕士研究生，主要从事药物载体的制备以及药物缓释方面的研究
通信作者：蔡玉荣，E-mail：caiy@zstu.edu.cn
更新日期/Last Update: 2021-09-16