|本期目录/Table of Contents|

[1]陈鹏,王耐艳,郑莹莹.聚氧化乙烯@明胶纤维制备及其生物性能探究[J].浙江理工大学学报,2019,41-42(自科一):56-64.
　CHEN peng,WANG Naiyan,ZHENG Yingying.Preparation and biological properties of Chitosan PEO@Gelatin nanofibers[J].Journal of Zhejiang Sci-Tech University,2019,41-42(自科一):56-64.
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聚氧化乙烯@明胶纤维制备及其生物性能探究()
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浙江理工大学学报[ISSN:1673-3851/CN:33-1338/TS]

卷:
第41-42卷
期数:
2019年自科一期
页码:
56-64
栏目:
出版日期:
2018-12-15

文章信息/Info

Title:
Preparation and biological properties of Chitosan PEO@Gelatin nanofibers
文章编号:
1673-3851 (2019) 01-0056-09
作者:
陈鹏;  王耐艳;  郑莹莹
浙江理工大学，a.理学院；b.材料与纺织学院，杭州 310018
Author(s):
CHEN peng;  WANG Naiyan;  ZHENG Yingying
a.School of Sciences; b.School of Materials and Textiles, Zhejiang  Sci-Tech University, Hangzhou 310018, China
关键词:
壳聚糖; 明胶; 同轴电纺; 细胞培养
分类号:
Q28
文献标志码:
A
摘要:
为提高壳聚糖的可纺性和生物相容性进行了材料设计。通过在壳聚糖（CS）乙酸溶液中引入高度可纺性的聚氧化乙烯（PEO）来提高壳聚糖的可纺性，并以高度可纺性的明胶（GEL）作为核模板，通过同轴静电纺丝技术进一步提高壳聚糖的可纺性，并制备出核壳结构的壳聚糖聚氧化乙烯@明胶（CSPEO@GEL）纤维。纺丝实验结果显示，CS和GEL浓度对纤维成型有显著影响，最佳条件为：CS浓度为3%（W/V），CS和PEO质量比为4∶1，GEL浓度为41%（W/V）；扫描电镜（SEM）和透射电镜（TEM）显示CSPEO@GEL纳米纤维表面均匀光滑，具有核壳结构，内径约为100 nm，外径约为150 nm；亲水性测试结果表明，亲水性较好的PEO和GEL能够明显提高CS的亲水性；骨肉瘤细胞MG63培养过程中，CSPEO@GEL纤维呈现出良好的生物相容性。所制备的CSPEO@GEL纤维材料在骨组织工程上具有潜在的研究价值。

参考文献/References:

［1］ Mourio V, Boccaccini A R. Bone tissue engineering therapeutics: Controlled drug delivery in threedimensional scaffolds［J］. Journal of the Royal Society Interface,2010,7(43):209-227.
［2］ Polocorrales L, Latorreesteves M, Ramirezvick J E. Scaffold design for bone regeneration［J］. Journal of Nanoscience & Nanotechnology,2014,14(1):15-56.
［3］ LogithKumar R, KeshavNarayan A, Dhivya S, et al. A review of chitosan and its derivatives in bone tissue engineering［J］. Carbohydrate Polymers,2016,151(1):172-188.
［4］ Desai K, Kit K, Li J, et al. Morphological and surface properties of electrospun chitosan nanofibers［J］. Biomacromolecules,2008,9(3):1000-1006.
［5］ Liu X D, Tokura S, Haruki M, et al. Surface modification of nonporous glass beads with chitosan and their adsorption  property for transition metal ions［J］.Carbohydrate Polymers,2002,49(2):103-108.
［6］ Bispo V M, Mansur A A P, BarbosaStancioli E F, et al. Biocompatibility of nanostructured chitosan/poly(vinyl alcohol) blends chemically crosslinked with genipin for biomedical applications［J］. Journal of Biomedical Nanotechnology,2010,6(2):166-175.
［7］ Duan B, Dong C, Yuan X, et al. Electrospinning of chitosan solutions in acetic acid with poly(ethylene oxide)［J］. Journal of Biomaterials SciencePolymer Edition,2004,15(6):797-811.
［8］ Alves N M, Mano J F. Chitosan derivatives obtained by chemical modifications for biomedical and environmental applications［J］. International Journal of Biological Macromolecules,2008,43(5):401-414.
［9］ Zhang Y, Su B, Ramakrishna S, et al. Chitosan nanofibers from an easily electrospinnable Uhmwpeodoped chitosan  solution system［J］. Biomacromolecules,2007,9(1):136-141.
［10］ Kousaku O, Dongil C, Hakyong K, et al. Electrospinning of chitosan［J］. Macromolecular Rapid Communications,2004,25(18):1600-1605.

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备注/Memo

备注/Memo:
收稿日期： 2017-03-22
网络出版日期： 2018-06-02
基金项目： 国家自然科学基金项目(51603187)；浙江省自然科学基金项目(LY15E030011)
作者简介： 陈鹏(1992-)，男，江苏南京人，硕士研究生，主要从事生物复合材料的制备以及生物性能方面的研究
通信作者： 郑莹莹，E-mail：zhengyy1718@zstu.edu.cn
更新日期/Last Update: 2019-03-13