|本期目录/Table of Contents|

[1]吴欣欣,李晓艳,武虎,等. 丁酸钠逆转H460/5FU肺癌细胞耐药性的研究[J].浙江理工大学学报,2012,29(04):609-613.
 WU Xin xin,LI Xiao yan,WU Hu,et al. Study on the Drug Resistance Reversal of Lung Cancer CellsH460/5FU by Sodium Butyrate[J].Journal of Zhejiang Sci-Tech University,2012,29(04):609-613.
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 丁酸钠逆转H460/5FU肺癌细胞耐药性的研究()
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浙江理工大学学报[ISSN:1673-3851/CN:33-1338/TS]

卷:
第29卷
期数:
2012年04期
页码:
609-613
栏目:
生物与生命科学
出版日期:
2012-08-28

文章信息/Info

Title:
 Study on the Drug Resistance Reversal of Lung Cancer CellsH460/5FU by Sodium Butyrate
文章编号:
16733851 (2012) 04060905
作者:
 吴欣欣 李晓艳 武虎 刘海燕 陈侃
 浙江理工大学生命科学学院新元医学与生物技术研究所, 杭州 310018
Author(s):
 WU Xinxin LI Xiaoyan WU Hu LIU Haiyan CHEN Kan
 Xinyuan Institute of Medcine and Biotechnology, School of Life Sciences, Zhejiang SciTechUniversity, Hangzhou 310018, China
关键词:
 肺癌 丁酸钠 SP细胞 耐药逆转
分类号:
Q733.7
文献标志码:
A
摘要:
     肺癌耐药是化疗成功的主要障碍,因此肺癌细胞的耐药逆转研究具重要意义。实验通过流式细胞术检测到对5氟脲嘧啶(5Fluorouracil,5FU)耐受的细胞系H460/5FU中的SP细胞含量较亲本细胞H460明显升高,经丁酸钠诱导分化后,H460/5FU对5FU的敏感性增加,表现为细胞存活率降低,细胞凋亡率提高,而且这种改变随着丁酸钠浓度的增加而增强。结果提示丁酸钠具备逆转肺癌耐药细胞系H460/5FU耐药的能力。

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期: 2011-10-31
基金项目: 国家自然科学基金(30801379);浙江理工大学科研启动基金(1016834-Y);浙江省重中之重学科开放基金项目(SWYX0812)
作者简介: 吴欣欣(1986-),女,山东德州人,硕士研究生,从事癌症的靶向基因病毒治疗的研究。
通讯作者: 陈侃,电子邮箱:chenkan_xjtu@163.com
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